LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice

The liver X receptor (LXR) signaling pathway is an important modulator of atherosclerosis, but the relative importance of the two LXRs in atheroprotection is incompletely understood. We show here that LXRα, the dominant LXR isotype expressed in liver, plays a particularly important role in whole-bod...

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Detalles Bibliográficos
Autores principales: Hong, Cynthia, Bradley, Michele N., Rong, Xin, Wang, Xuping, Wagner, Alan, Grijalva, Victor, Castellani, Lawrence W., Salazar, Jon, Realegeno, Susan, Boyadjian, Rima, Fogelman, Alan M., Van Lenten, Brian J., Reddy, Srinivasa T., Lusis, Aldons J., Tangirala, Rajendra K., Tontonoz, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351819/
https://www.ncbi.nlm.nih.gov/pubmed/22454476
http://dx.doi.org/10.1194/jlr.M022061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351819/
https://www.ncbi.nlm.nih.gov/pubmed/22454476
http://dx.doi.org/10.1194/jlr.M022061

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