Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations

Missense mutations of the phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) gene cause autosomal-recessive Parkinson's disease. To date, little is known about the intrinsic catalytic properties of PINK1 since the human enzyme displays such low kinase activity in vitro. We have disc...

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Detalles Bibliográficos
Autores principales: Woodroof, Helen I., Pogson, Joe H., Begley, Mike, Cantley, Lewis C., Deak, Maria, Campbell, David G., van Aalten, Daan M. F., Whitworth, Alexander J., Alessi, Dario R., Muqit, Miratul M. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352081/
https://www.ncbi.nlm.nih.gov/pubmed/22645651
http://dx.doi.org/10.1098/rsob.110012

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