Cargando…

The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled

Most cases of colorectal cancer are linked to mutational inactivation of the Adenomatous polyposis coli (APC) tumour suppressor. APC downregulates Wnt signalling by enabling Axin to promote the degradation of the Wnt signalling effector β-catenin (Armadillo in flies). This depends on Axin's DIX...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mendoza-Topaz, Carolina, Mieszczanek, Juliusz, Bienz, Mariann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352083/ https://www.ncbi.nlm.nih.gov/pubmed/22645652 http://dx.doi.org/10.1098/rsob.110013

Ejemplares similares

Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin
por: Gammons, Melissa V, et al.
Publicado: (2020)

Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation
por: Li, Tie-Mei, et al.
Publicado: (2020)

Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction
por: Kan, Wei, et al.
Publicado: (2020)

The structural and functional determinants of the Axin and Dishevelled DIX domains
por: Ehebauer, Matthias T, et al.
Publicado: (2009)

Assembly of Dishevelled 3-based supermolecular complexes via phosphorylation and Axin
por: Yokoyama, Noriko, et al.
Publicado: (2012)

Different Roles for the Axin Interactions with the SAMP versus the Second Twenty Amino Acid Repeat of Adenomatous Polyposis Coli
por: Schneikert, Jean, et al.
Publicado: (2014)

Selective function of the PDZ domain of Dishevelled in noncanonical Wnt signalling
por: Mieszczanek, Juliusz, et al.
Publicado: (2022)

Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin
por: Babcock, Rachel L., et al.
Publicado: (2022)

Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled
por: Mund, Thomas, et al.
Publicado: (2015)

Intracellular shuttling of a Drosophila APC tumour suppressor homolog
por: Cliffe, Adam, et al.
Publicado: (2004)

An American patient with polyposis carrying a Scandinavian AXIN2 pathogenic variant
por: Macklin-Mantia, Sarah K., et al.
Publicado: (2020)

A novel pathogenic frameshift variant in AXIN2 in a man with polyposis and hypodontia
por: Broekema, M. F., et al.
Publicado: (2023)

Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines
por: Wang, Wenhui, et al.
Publicado: (2021)

Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta
por: Martino-Echarri, Estefania, et al.
Publicado: (2016)

The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration
por: Mastrogiovanni, Marta, et al.
Publicado: (2022)

Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting Axin-GSK3 interaction
por: Ahn, Sung Yong, et al.
Publicado: (2017)

Analysis of adenomatous polyposis coli gene in thyroid tumours.
por: Colletta, G., et al.
Publicado: (1994)

Genome Sequence of “Candidatus Walczuchella monophlebidarum” the Flavobacterial Endosymbiont of Llaveia axin axin (Hemiptera: Coccoidea: Monophlebidae)
por: Rosas-Pérez, Tania, et al.
Publicado: (2014)

Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation
por: Thorvaldsen, Tor Espen, et al.
Publicado: (2017)

Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2
por: Ruane, Peter T., et al.
Publicado: (2016)

PLK1 Interacts and Phosphorylates Axin That Is Essential for Proper Centrosome Formation
por: Ruan, Ka, et al.
Publicado: (2012)

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex
por: Schaefer, Kristina N., et al.
Publicado: (2020)

Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC
por: Tacchelly-Benites, Ofelia, et al.
Publicado: (2018)

Tumor suppressor genes in familial adenomatous polyposis
por: Eshghifar, Nahal, et al.
Publicado: (2017)

Adenomatous Polyposis Coli Gene Mutations in 22 Chinese Pedigrees with Familial Adenomatous Polyposis
por: Wang, Dan, et al.
Publicado: (2019)

Expression of β-catenin and AXIN2 in ameloblastomas
por: Wei, Zhenhui, et al.
Publicado: (2013)

Emerging roles of Axin in cerebral cortical development
por: Ye, Tao, et al.
Publicado: (2015)

AXIN2 is Associated With Papillary Thyroid Carcinoma
por: Liu, Xin, et al.
Publicado: (2016)

AXIN-AMPK signaling: Implications for healthy aging
por: Mallick, Avijit, et al.
Publicado: (2021)

Reduced expression of Axin correlates with tumour progression of oesophageal squamous cell carcinoma
por: Nakajima, M, et al.
Publicado: (2003)

An AXIN2 Mutant Allele Associated With Predisposition to Colorectal Neoplasia Has Context-Dependent Effects on AXIN2 Protein Function()
por: Mazzoni, Serina M., et al.
Publicado: (2015)

A novel frameshift mutation in exon 12 of the adenomatous polyposis coli gene in an Italian family with familial adenomatous polyposis and desmoid tumour
por: Teresa, Vietri Maria, et al.
Publicado: (2010)

Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled
por: Gammons, Melissa V., et al.
Publicado: (2016)

Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5
por: Flack, Joshua E., et al.
Publicado: (2017)

Erratum to: A novel frameshift mutation in exon 12 of the adenomatous polyposis coli gene in an Italian family with familial adenomatous polyposis and desmoid tumour
por: Teresa, Vietri Maria, et al.
Publicado: (2010)

Expression Pattern of Axin2 During Chicken Development
por: Eckei, Gesa, et al.
Publicado: (2016)

Axin2/Conductin Is Required for Normal Haematopoiesis and T Lymphopoiesis
por: de Roo, Jolanda J. D., et al.
Publicado: (2022)

Frequent loss of the AXIN1 locus but absence of AXIN1 gene mutations in adenocarcinomas of the gastro-oesophageal junction with nuclear β-catenin expression
por: Koppert, L B, et al.
Publicado: (2004)

Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours.
por: Giarola, M., et al.
Publicado: (1998)

Immunopurification of adenomatous polyposis coli (APC) proteins
por: Elliott, Kerryn L, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_urqhr35utq0k6ggnuroajcc5vv