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Skull Metastasis as Initial Manifestation of Pulmonary Epithelial-Myoepithelial Carcinoma: A Case Report of an Unusual Case
Epithelial-myoepithelial carcinoma (EMC) of the lung is rare and is considered to be low-grade malignancy. Intracranial metastasis of pulmonary EMC has not previously been reported according to our search of the literature. We report a case of skull metastasis as the initial manifestation of pulmona...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352177/ https://www.ncbi.nlm.nih.gov/pubmed/22629483 http://dx.doi.org/10.1155/2011/610383 |
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author | Nishihara, Masamitsu Takeda, Naoya Tatsumi, Shoutarou Kidoguchi, Keiji Hayashi, Shigeto Sasayama, Takashi Kohmura, Eiji Hashimoto, Kimio |
author_facet | Nishihara, Masamitsu Takeda, Naoya Tatsumi, Shoutarou Kidoguchi, Keiji Hayashi, Shigeto Sasayama, Takashi Kohmura, Eiji Hashimoto, Kimio |
author_sort | Nishihara, Masamitsu |
collection | PubMed |
description | Epithelial-myoepithelial carcinoma (EMC) of the lung is rare and is considered to be low-grade malignancy. Intracranial metastasis of pulmonary EMC has not previously been reported according to our search of the literature. We report a case of skull metastasis as the initial manifestation of pulmonary EMC. An 81-year-old man complained of left leg motor weakness. Neurological examination showed left hemiparesis. Computed tomography and magnetic resonance imaging revealed an osteolytic tumor in the right frontal bone with invasion to the dura and subdural space, attached to the superior sagittal sinus. Subtotal removal of the tumor was performed, and the left hemiparesis showed improvement. Histopathological study revealed the tumor to consist of epithelial and myoepithelial cells. Pulmonary EMC was diagnosed. The MIB-1 index in primary lesion was approximately 10%. The skull and dura are possible sites for metastasis from pulmonary EMC. The MIB-1 index is a predictive marker of malignant potential. |
format | Online Article Text |
id | pubmed-3352177 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33521772012-05-24 Skull Metastasis as Initial Manifestation of Pulmonary Epithelial-Myoepithelial Carcinoma: A Case Report of an Unusual Case Nishihara, Masamitsu Takeda, Naoya Tatsumi, Shoutarou Kidoguchi, Keiji Hayashi, Shigeto Sasayama, Takashi Kohmura, Eiji Hashimoto, Kimio Case Rep Oncol Med Case Report Epithelial-myoepithelial carcinoma (EMC) of the lung is rare and is considered to be low-grade malignancy. Intracranial metastasis of pulmonary EMC has not previously been reported according to our search of the literature. We report a case of skull metastasis as the initial manifestation of pulmonary EMC. An 81-year-old man complained of left leg motor weakness. Neurological examination showed left hemiparesis. Computed tomography and magnetic resonance imaging revealed an osteolytic tumor in the right frontal bone with invasion to the dura and subdural space, attached to the superior sagittal sinus. Subtotal removal of the tumor was performed, and the left hemiparesis showed improvement. Histopathological study revealed the tumor to consist of epithelial and myoepithelial cells. Pulmonary EMC was diagnosed. The MIB-1 index in primary lesion was approximately 10%. The skull and dura are possible sites for metastasis from pulmonary EMC. The MIB-1 index is a predictive marker of malignant potential. Hindawi Publishing Corporation 2011 2011-07-12 /pmc/articles/PMC3352177/ /pubmed/22629483 http://dx.doi.org/10.1155/2011/610383 Text en Copyright © 2011 Masamitsu Nishihara et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Nishihara, Masamitsu Takeda, Naoya Tatsumi, Shoutarou Kidoguchi, Keiji Hayashi, Shigeto Sasayama, Takashi Kohmura, Eiji Hashimoto, Kimio Skull Metastasis as Initial Manifestation of Pulmonary Epithelial-Myoepithelial Carcinoma: A Case Report of an Unusual Case |
title | Skull Metastasis as Initial Manifestation of Pulmonary Epithelial-Myoepithelial Carcinoma: A Case Report of an Unusual Case |
title_full | Skull Metastasis as Initial Manifestation of Pulmonary Epithelial-Myoepithelial Carcinoma: A Case Report of an Unusual Case |
title_fullStr | Skull Metastasis as Initial Manifestation of Pulmonary Epithelial-Myoepithelial Carcinoma: A Case Report of an Unusual Case |
title_full_unstemmed | Skull Metastasis as Initial Manifestation of Pulmonary Epithelial-Myoepithelial Carcinoma: A Case Report of an Unusual Case |
title_short | Skull Metastasis as Initial Manifestation of Pulmonary Epithelial-Myoepithelial Carcinoma: A Case Report of an Unusual Case |
title_sort | skull metastasis as initial manifestation of pulmonary epithelial-myoepithelial carcinoma: a case report of an unusual case |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352177/ https://www.ncbi.nlm.nih.gov/pubmed/22629483 http://dx.doi.org/10.1155/2011/610383 |
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