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Mutations in the C-terminal region of the HIV-1 reverse transcriptase and their correlation with drug resistance associated mutations and antiviral treatment

OBJECTIVE: Replication of HIV-1 after cell entry is essentially dependent on the reverse transcriptase (RT). Antiretroviral drugs impairing the function of the RT currently aim at the polymerase subunit. One reason for failure of antiretroviral treatment is the evolvement of resistance-associated mu...

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Detalles Bibliográficos
Autores principales:	Michels, I, Staszewski, S, Gürtler, L, Nisius, G, Müller, A, Locher, L, Doerr, H-W, Stürmer, M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352185/ https://www.ncbi.nlm.nih.gov/pubmed/21156400 http://dx.doi.org/10.1186/2047-783X-15-10-415

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