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Cytokines and HCV-Related Disorders
Cytokines are intercellular mediators involved in viral control and liver damage being induced by infection with hepatitis C virus (HCV). The complex cytokine network operating during initial infection allows a coordinated, effective development of both innate and adaptive immune responses. However,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352261/ https://www.ncbi.nlm.nih.gov/pubmed/22611419 http://dx.doi.org/10.1155/2012/468107 |
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author | Fallahi, Poupak Ferri, Clodoveo Ferrari, Silvia Martina Corrado, Alda Sansonno, Domenico Antonelli, Alessandro |
author_facet | Fallahi, Poupak Ferri, Clodoveo Ferrari, Silvia Martina Corrado, Alda Sansonno, Domenico Antonelli, Alessandro |
author_sort | Fallahi, Poupak |
collection | PubMed |
description | Cytokines are intercellular mediators involved in viral control and liver damage being induced by infection with hepatitis C virus (HCV). The complex cytokine network operating during initial infection allows a coordinated, effective development of both innate and adaptive immune responses. However, HCV interferes with cytokines at various levels and escapes immune response by inducing a T-helper (Th)2/T cytotoxic 2 cytokine profile. Inability to control infection leads to the recruitment of inflammatory infiltrates into the liver parenchyma by interferon (IFN)-gamma-inducible CXC chemokine ligand (CXCL)-9, -10, and -11 chemokines, which results in sustained liver damage and eventually in liver cirrhosis. The most important systemic HCV-related extrahepatic diseases—mixed cryoglobulinemia, lymphoproliferative disorders, thyroid autoimmune disorders, and type 2 diabetes—are associated with a complex dysregulation of the cytokine/chemokine network, involving proinflammatory and Th1 chemokines. The therapeutical administration of cytokines such as IFN-alpha may result in viral clearance during persistent infection and reverts this process. |
format | Online Article Text |
id | pubmed-3352261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33522612012-05-18 Cytokines and HCV-Related Disorders Fallahi, Poupak Ferri, Clodoveo Ferrari, Silvia Martina Corrado, Alda Sansonno, Domenico Antonelli, Alessandro Clin Dev Immunol Review Article Cytokines are intercellular mediators involved in viral control and liver damage being induced by infection with hepatitis C virus (HCV). The complex cytokine network operating during initial infection allows a coordinated, effective development of both innate and adaptive immune responses. However, HCV interferes with cytokines at various levels and escapes immune response by inducing a T-helper (Th)2/T cytotoxic 2 cytokine profile. Inability to control infection leads to the recruitment of inflammatory infiltrates into the liver parenchyma by interferon (IFN)-gamma-inducible CXC chemokine ligand (CXCL)-9, -10, and -11 chemokines, which results in sustained liver damage and eventually in liver cirrhosis. The most important systemic HCV-related extrahepatic diseases—mixed cryoglobulinemia, lymphoproliferative disorders, thyroid autoimmune disorders, and type 2 diabetes—are associated with a complex dysregulation of the cytokine/chemokine network, involving proinflammatory and Th1 chemokines. The therapeutical administration of cytokines such as IFN-alpha may result in viral clearance during persistent infection and reverts this process. Hindawi Publishing Corporation 2012 2012-05-07 /pmc/articles/PMC3352261/ /pubmed/22611419 http://dx.doi.org/10.1155/2012/468107 Text en Copyright © 2012 Poupak Fallahi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fallahi, Poupak Ferri, Clodoveo Ferrari, Silvia Martina Corrado, Alda Sansonno, Domenico Antonelli, Alessandro Cytokines and HCV-Related Disorders |
title | Cytokines and HCV-Related Disorders |
title_full | Cytokines and HCV-Related Disorders |
title_fullStr | Cytokines and HCV-Related Disorders |
title_full_unstemmed | Cytokines and HCV-Related Disorders |
title_short | Cytokines and HCV-Related Disorders |
title_sort | cytokines and hcv-related disorders |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352261/ https://www.ncbi.nlm.nih.gov/pubmed/22611419 http://dx.doi.org/10.1155/2012/468107 |
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