Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid

Thymidylate synthase (TS) enzymes catalyse the biosynthesis of deoxythymidine monophosphate (dTMP or thymidylate), and so are important for DNA replication and repair. Two different types of TS proteins have been described (ThyA and ThyX), which have different enzymic mechanisms and unrelated struct...

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Detalles Bibliográficos
Autores principales: Fivian-Hughes, Amanda S., Houghton, Joanna, Davis, Elaine O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for General Microbiology 2012
Materias:
Cell and Molecular Biology of Microbes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352284/
https://www.ncbi.nlm.nih.gov/pubmed/22034487
http://dx.doi.org/10.1099/mic.0.053983-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352284/
https://www.ncbi.nlm.nih.gov/pubmed/22034487
http://dx.doi.org/10.1099/mic.0.053983-0

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