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A case of clear cell adenocarcinoma arising from the urethral diverticulum: Utility of urinary cytology and immunohistochemistry

Carcinomas rarely arise from the urethral diverticulum. In this report, we present a case of clear cell adenocarcinoma arising from the urethral diverticulum. A 42-year-old woman complained of bloody discharge and lower back pain. Imaging studies showed a tumor involving the region surrounding the u...

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Autores principales: Nakatsuka, Shin-ichi, Taguchi, Isao, Nagatomo, Tadasuke, Yamane, Michiaki, Sugio, Kenji, Yoshino, Ryuichi, Oku, Kazuko, Nagano, Teruaki, Kimura, Hayato, Nakajo, Kazuya, Kawabata, Gaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352587/
https://www.ncbi.nlm.nih.gov/pubmed/22615710
http://dx.doi.org/10.4103/1742-6413.95528
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author Nakatsuka, Shin-ichi
Taguchi, Isao
Nagatomo, Tadasuke
Yamane, Michiaki
Sugio, Kenji
Yoshino, Ryuichi
Oku, Kazuko
Nagano, Teruaki
Kimura, Hayato
Nakajo, Kazuya
Kawabata, Gaku
author_facet Nakatsuka, Shin-ichi
Taguchi, Isao
Nagatomo, Tadasuke
Yamane, Michiaki
Sugio, Kenji
Yoshino, Ryuichi
Oku, Kazuko
Nagano, Teruaki
Kimura, Hayato
Nakajo, Kazuya
Kawabata, Gaku
author_sort Nakatsuka, Shin-ichi
collection PubMed
description Carcinomas rarely arise from the urethral diverticulum. In this report, we present a case of clear cell adenocarcinoma arising from the urethral diverticulum. A 42-year-old woman complained of bloody discharge and lower back pain. Imaging studies showed a tumor involving the region surrounding the urethra and cystourethroscopy showed papillary and villous tumors in the urethral diverticula. Cytology of the urine sediment showed papillary or spherical clusters of atypical cells, some of which had clear abundant cytoplasm and formed mirror ball-like clusters, suggesting adenocarcinoma. Although histological diagnosis was indeterminate by biopsy and transurethral resection (TUR) because of absence of stromal invasion, surgically resected specimen via cysturethrectomy revealed that the tumor was clear cell carcinoma. Urinary cytological findings and immunohistochemical analysis for CD15, Ki-67, and p53 might be useful for accurate diagnosis of clear cell adenocarcinoma that arises from the urethral diverticulum when sufficient materials are not available by biopsy and TUR.
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spelling pubmed-33525872012-05-21 A case of clear cell adenocarcinoma arising from the urethral diverticulum: Utility of urinary cytology and immunohistochemistry Nakatsuka, Shin-ichi Taguchi, Isao Nagatomo, Tadasuke Yamane, Michiaki Sugio, Kenji Yoshino, Ryuichi Oku, Kazuko Nagano, Teruaki Kimura, Hayato Nakajo, Kazuya Kawabata, Gaku Cytojournal Case Report Carcinomas rarely arise from the urethral diverticulum. In this report, we present a case of clear cell adenocarcinoma arising from the urethral diverticulum. A 42-year-old woman complained of bloody discharge and lower back pain. Imaging studies showed a tumor involving the region surrounding the urethra and cystourethroscopy showed papillary and villous tumors in the urethral diverticula. Cytology of the urine sediment showed papillary or spherical clusters of atypical cells, some of which had clear abundant cytoplasm and formed mirror ball-like clusters, suggesting adenocarcinoma. Although histological diagnosis was indeterminate by biopsy and transurethral resection (TUR) because of absence of stromal invasion, surgically resected specimen via cysturethrectomy revealed that the tumor was clear cell carcinoma. Urinary cytological findings and immunohistochemical analysis for CD15, Ki-67, and p53 might be useful for accurate diagnosis of clear cell adenocarcinoma that arises from the urethral diverticulum when sufficient materials are not available by biopsy and TUR. Medknow Publications & Media Pvt Ltd 2012-04-30 /pmc/articles/PMC3352587/ /pubmed/22615710 http://dx.doi.org/10.4103/1742-6413.95528 Text en Copyright: © 2012 Nakatsuka, et al.; licensee Cytopathology Foundation Inc http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Nakatsuka, Shin-ichi
Taguchi, Isao
Nagatomo, Tadasuke
Yamane, Michiaki
Sugio, Kenji
Yoshino, Ryuichi
Oku, Kazuko
Nagano, Teruaki
Kimura, Hayato
Nakajo, Kazuya
Kawabata, Gaku
A case of clear cell adenocarcinoma arising from the urethral diverticulum: Utility of urinary cytology and immunohistochemistry
title A case of clear cell adenocarcinoma arising from the urethral diverticulum: Utility of urinary cytology and immunohistochemistry
title_full A case of clear cell adenocarcinoma arising from the urethral diverticulum: Utility of urinary cytology and immunohistochemistry
title_fullStr A case of clear cell adenocarcinoma arising from the urethral diverticulum: Utility of urinary cytology and immunohistochemistry
title_full_unstemmed A case of clear cell adenocarcinoma arising from the urethral diverticulum: Utility of urinary cytology and immunohistochemistry
title_short A case of clear cell adenocarcinoma arising from the urethral diverticulum: Utility of urinary cytology and immunohistochemistry
title_sort case of clear cell adenocarcinoma arising from the urethral diverticulum: utility of urinary cytology and immunohistochemistry
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352587/
https://www.ncbi.nlm.nih.gov/pubmed/22615710
http://dx.doi.org/10.4103/1742-6413.95528
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