Cargando…
Coccidian Infection Causes Oxidative Damage in Greenfinches
The main tenet of immunoecology is that individual variation in immune responsiveness is caused by the costs of immune responses to the hosts. Oxidative damage resulting from the excessive production of reactive oxygen species during immune response is hypothesized to form one of such costs. We test...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352913/ https://www.ncbi.nlm.nih.gov/pubmed/22615772 http://dx.doi.org/10.1371/journal.pone.0036495 |
_version_ | 1782232978310561792 |
---|---|
author | Sepp, Tuul Karu, Ulvi Blount, Jonathan D. Sild, Elin Männiste, Marju Hõrak, Peeter |
author_facet | Sepp, Tuul Karu, Ulvi Blount, Jonathan D. Sild, Elin Männiste, Marju Hõrak, Peeter |
author_sort | Sepp, Tuul |
collection | PubMed |
description | The main tenet of immunoecology is that individual variation in immune responsiveness is caused by the costs of immune responses to the hosts. Oxidative damage resulting from the excessive production of reactive oxygen species during immune response is hypothesized to form one of such costs. We tested this hypothesis in experimental coccidian infection model in greenfinches Carduelis chloris. Administration of isosporan coccidians to experimental birds did not affect indices of antioxidant protection (TAC and OXY), plasma triglyceride and carotenoid levels or body mass, indicating that pathological consequences of infection were generally mild. Infected birds had on average 8% higher levels of plasma malondialdehyde (MDA, a toxic end-product of lipid peroxidation) than un-infected birds. The birds that had highest MDA levels subsequent to experimental infection experienced the highest decrease in infection intensity. This observation is consistent with the idea that oxidative stress is a causative agent in the control of coccidiosis and supports the concept of oxidative costs of immune responses and parasite resistance. The finding that oxidative damage accompanies even the mild infection with a common parasite highlights the relevance of oxidative stress biology for the immunoecological research. |
format | Online Article Text |
id | pubmed-3352913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-33529132012-05-21 Coccidian Infection Causes Oxidative Damage in Greenfinches Sepp, Tuul Karu, Ulvi Blount, Jonathan D. Sild, Elin Männiste, Marju Hõrak, Peeter PLoS One Research Article The main tenet of immunoecology is that individual variation in immune responsiveness is caused by the costs of immune responses to the hosts. Oxidative damage resulting from the excessive production of reactive oxygen species during immune response is hypothesized to form one of such costs. We tested this hypothesis in experimental coccidian infection model in greenfinches Carduelis chloris. Administration of isosporan coccidians to experimental birds did not affect indices of antioxidant protection (TAC and OXY), plasma triglyceride and carotenoid levels or body mass, indicating that pathological consequences of infection were generally mild. Infected birds had on average 8% higher levels of plasma malondialdehyde (MDA, a toxic end-product of lipid peroxidation) than un-infected birds. The birds that had highest MDA levels subsequent to experimental infection experienced the highest decrease in infection intensity. This observation is consistent with the idea that oxidative stress is a causative agent in the control of coccidiosis and supports the concept of oxidative costs of immune responses and parasite resistance. The finding that oxidative damage accompanies even the mild infection with a common parasite highlights the relevance of oxidative stress biology for the immunoecological research. Public Library of Science 2012-05-15 /pmc/articles/PMC3352913/ /pubmed/22615772 http://dx.doi.org/10.1371/journal.pone.0036495 Text en Sepp et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Sepp, Tuul Karu, Ulvi Blount, Jonathan D. Sild, Elin Männiste, Marju Hõrak, Peeter Coccidian Infection Causes Oxidative Damage in Greenfinches |
title | Coccidian Infection Causes Oxidative Damage in Greenfinches |
title_full | Coccidian Infection Causes Oxidative Damage in Greenfinches |
title_fullStr | Coccidian Infection Causes Oxidative Damage in Greenfinches |
title_full_unstemmed | Coccidian Infection Causes Oxidative Damage in Greenfinches |
title_short | Coccidian Infection Causes Oxidative Damage in Greenfinches |
title_sort | coccidian infection causes oxidative damage in greenfinches |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352913/ https://www.ncbi.nlm.nih.gov/pubmed/22615772 http://dx.doi.org/10.1371/journal.pone.0036495 |
work_keys_str_mv | AT sepptuul coccidianinfectioncausesoxidativedamageingreenfinches AT karuulvi coccidianinfectioncausesoxidativedamageingreenfinches AT blountjonathand coccidianinfectioncausesoxidativedamageingreenfinches AT sildelin coccidianinfectioncausesoxidativedamageingreenfinches AT mannistemarju coccidianinfectioncausesoxidativedamageingreenfinches AT horakpeeter coccidianinfectioncausesoxidativedamageingreenfinches |