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Hyperphosphorylation and Cleavage at D421 Enhance Tau Secretion

It is well established that tau pathology propagates in a predictable manner in Alzheimer’s disease (AD). Moreover, tau accumulates in the cerebrospinal fluid (CSF) of AD’s patients. The mechanisms underlying the propagation of tau pathology and its accumulation in the CSF remain to be elucidated. R...

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Detalles Bibliográficos
Autores principales:	Plouffe, Vanessa, Mohamed, Nguyen-Vi, Rivest-McGraw, Jessica, Bertrand, Johanne, Lauzon, Michel, Leclerc, Nicole
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352936/ https://www.ncbi.nlm.nih.gov/pubmed/22615831 http://dx.doi.org/10.1371/journal.pone.0036873

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