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Urea uptake enhances barrier function and antimicrobial defense in humans by regulating epidermal gene expression

Urea is an endogenous metabolite, known to enhance stratum corneum hydration. Yet, topical urea anecdotally also improves permeability barrier function, and it appears to exhibit antimicrobial activity. Hence, we hypothesized that urea is not merely a passive metabolite, but a small-molecule regulat...

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Detalles Bibliográficos
Autores principales:	Grether-Beck, Susanne, Felsner, Ingo, Brenden, Heidi, Kohne, Zippora, Majora, Marc, Marini, Alessandra, Jaenicke, Thomas, Rodriguez-Martin, Marina, Trullas, Carles, Hupe, Melanie, Elias, Peter M., Krutmann, Jean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352965/ https://www.ncbi.nlm.nih.gov/pubmed/22418868 http://dx.doi.org/10.1038/jid.2012.42

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