Cargando…

Urea uptake enhances barrier function and antimicrobial defense in humans by regulating epidermal gene expression

Urea is an endogenous metabolite, known to enhance stratum corneum hydration. Yet, topical urea anecdotally also improves permeability barrier function, and it appears to exhibit antimicrobial activity. Hence, we hypothesized that urea is not merely a passive metabolite, but a small-molecule regulat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grether-Beck, Susanne, Felsner, Ingo, Brenden, Heidi, Kohne, Zippora, Majora, Marc, Marini, Alessandra, Jaenicke, Thomas, Rodriguez-Martin, Marina, Trullas, Carles, Hupe, Melanie, Elias, Peter M., Krutmann, Jean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352965/ https://www.ncbi.nlm.nih.gov/pubmed/22418868 http://dx.doi.org/10.1038/jid.2012.42

Ejemplares similares

Urea in Dermatology: A Review of its Emollient, Moisturizing, Keratolytic, Skin Barrier Enhancing and Antimicrobial Properties
por: Piquero-Casals, Jaime, et al.
Publicado: (2021)

Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammation
por: Peuschel, Henrike, et al.
Publicado: (2012)

MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4
por: Lang, Alexander, et al.
Publicado: (2016)

Daily photoprotection: What does it really mean?
por: Krutmann, Jean, et al.
Publicado: (2021)

A gene variant of AKR1C3 contributes to interindividual susceptibilities to atopic dermatitis triggered by particulate air pollution
por: Vogeley, Christian, et al.
Publicado: (2023)

EXPRESSION OF EPIDERMAL CAMP CHANGES IN PARALLEL WITH PERMEABILITY BARRIER STATUS
por: Rodriguez-Martin, Marina, et al.
Publicado: (2011)

Increased levels of large scale deletions of mtDNA of skin fibroblasts result in increased collagen degradation in dermal skin equivalents
por: Schuermann, BA, et al.
Publicado: (2009)

Linear and exponential sunscreen behaviours as an explanation for observed discrepancies in sun protection factor testing
por: Trullàs, Carles, et al.
Publicado: (2019)

Functional consequences of mitochondrial DNA deletions in human skin fibroblasts: increased contractile strength in collagen lattices is due to oxidative stress-induced lysyl oxidase activity
por: Majora, M, et al.
Publicado: (2009)

An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study
por: Cai, Carr, et al.
Publicado: (2023)

Evaluation of a Sunscreen Product Compared with Reference Standards P3, P5 and P8 in Outdoor Conditions: a Randomized, Double-Blinded, Intra-individual Study in Healthy Subjects
por: Granger, Corinne, et al.
Publicado: (2022)

New Methodology to Evaluate Sunscreens Under Outdoor Conditions: A Double-Blind, Randomized Intra-Individual Clinical Study of a Water-Based Broad-Spectrum SPF50+ Versus SPF15 (P3) and SPF50+
por: Granger, Corinne, et al.
Publicado: (2019)

Prevention of Polymorphic Light Eruption Afforded by a Very High Broad-Spectrum Protection Sunscreen Containing Ectoin
por: Duteil, Luc, et al.
Publicado: (2022)

Systematic Identification and Characterization of Novel Human Skin-Associated Genes Encoding Membrane and Secreted Proteins
por: Gerber, Peter Arne, et al.
Publicado: (2013)

Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory TNF‐alpha in human skin explants
por: Narda, Mridvika, et al.
Publicado: (2020)

Commentary: Facial Aesthetic Dermatological Procedures and Photoprotection in Chinese Populations
por: Liu, Wei, et al.
Publicado: (2022)

Outdoor sunscreen testing with high‐intensity solar exposure in a Chinese and Caucasian population
por: Granger, Corinne, et al.
Publicado: (2021)

Evidence for Active Uptake and Deposition of Si-based Defenses in Tall Fescue
por: McLarnon, Emma, et al.
Publicado: (2017)

Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy
por: Morita, Akimichi, et al.
Publicado: (1997)

Hierarchical and Dynamic Regulation of Defense-Responsive Specialized Metabolism by WRKY and MYB Transcription Factors
por: Barco, Brenden, et al.
Publicado: (2020)

Nrf2 links epidermal barrier function with antioxidant defense
por: Schäfer, Matthias, et al.
Publicado: (2012)

Lys-urea-Aad, Lys-urea-Cmc and Lys-urea-Cms as potential pharmacophores for the design of PSMA-targeted radioligands to reduce off-target uptake in kidneys and salivary glands
por: Kuo, Hsiou-Ting, et al.
Publicado: (2023)

A new cyanogenic metabolite in Arabidopsis required for inducible pathogen defense
por: Rajniak, Jakub, et al.
Publicado: (2015)

Physiological and Molecular Investigation of Urea Uptake Dynamics in Cucumis sativus L. Plants Fertilized With Urea-Doped Amorphous Calcium Phosphate Nanoparticles
por: Feil, Sebastian B., et al.
Publicado: (2021)

Comparative Study Effect of Urea-Sulfur Fertilizers on Nitrogen Uptake and Maize Productivity
por: Swify, Samar, et al.
Publicado: (2022)

Topical Hesperidin Enhances Epidermal Function in an Aged Murine Model
por: Man, George, et al.
Publicado: (2014)

Expansion of a core regulon by transposable elements promotes Arabidopsis chemical diversity and pathogen defense
por: Barco, Brenden, et al.
Publicado: (2019)

Effectiveness of problem-based learning methodology in undergraduate medical education: a scoping review
por: Trullàs, Joan Carles, et al.
Publicado: (2022)

Paradoxical Benefits of Psychological Stress in Inflammatory Dermatoses Models Are Glucocorticoid Mediated
por: Lin, Tzu-Kai, et al.
Publicado: (2014)

Neuroprotective Properties of Dimethyl Fumarate Measured by Optical Coherence Tomography in Non-inflammatory Animal Models
por: Dietrich, Michael, et al.
Publicado: (2021)

The Signal Transduction Protein P(II) Controls Ammonium, Nitrate and Urea Uptake in Cyanobacteria
por: Watzer, Björn, et al.
Publicado: (2019)

Zinc- and magnesium-doped hydroxyapatite-urea nanohybrids enhance wheat growth and nitrogen uptake
por: Sharma, Bhaskar, et al.
Publicado: (2022)

Macrocyclic bis(ureas) as ligands for anion complexation
por: Kretschmer, Claudia, et al.
Publicado: (2014)

Epidermal chloroplasts are defense-related motile organelles equipped with plant immune components
por: Irieda, Hiroki, et al.
Publicado: (2021)

Outdoor testing of the photoprotection provided by a new water-based broad-spectrum SPF50+ sunscreen product: two double-blind, split-face, randomized controlled studies in healthy adults
por: Granger, Corinne, et al.
Publicado: (2019)

Genetically Programmed Differences in Epidermal Host Defense between Psoriasis and Atopic Dermatitis Patients
por: Zeeuwen, Patrick L. J. M., et al.
Publicado: (2008)

BMAL1 Modulates Epidermal Healing in a Process Involving the Antioxidative Defense Mechanism
por: Silveira, Ericka J. D., et al.
Publicado: (2020)

Epidermal growth factor alleviates the negative impact of urea on frozen-thawed bovine sperm, but the subsequent developmental competence is compromised
por: Kowsar, Rasoul, et al.
Publicado: (2021)

Exposome and Skin: Part 1. Bibliometric Analysis and Review of the Impact of Exposome Approaches on Dermatology
por: Molina-García, Manuel, et al.
Publicado: (2022)

Inhibition of Nematocyst Discharge from Pelagia noctiluca (Cnidaria: Scyphozoa)—Prevention Measures against Jellyfish Stings
por: Ballesteros, Ainara, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0om00b1jb5fulnrigc0nbar6j5