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Association of Vitamin A and Carotenoid Intake with Melanoma Risk in a Large Prospective Cohort
Laboratory data suggest that intake of vitamin A and carotenoids, may have chemopreventive benefits against melanoma, but epidemiologic studies examining the association have yielded conflicting results. We examined whether dietary and supplemental vitamin A and carotenoid intake was associated with...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352977/ https://www.ncbi.nlm.nih.gov/pubmed/22377763 http://dx.doi.org/10.1038/jid.2012.21 |
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author | Asgari, Maryam M. Brasky, Theodore M. White, Emily |
author_facet | Asgari, Maryam M. Brasky, Theodore M. White, Emily |
author_sort | Asgari, Maryam M. |
collection | PubMed |
description | Laboratory data suggest that intake of vitamin A and carotenoids, may have chemopreventive benefits against melanoma, but epidemiologic studies examining the association have yielded conflicting results. We examined whether dietary and supplemental vitamin A and carotenoid intake was associated with melanoma risk among 69,635 men and women who were participants of the Vitamins and Lifestyle (VITAL) cohort study in Western Washington. After an average of 5.84 years of follow-up, 566 incident melanomas were identified. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for risk of melanoma associated with dietary, supplement and total vitamin A and carotenoid intake after adjusting for melanoma risk factors. Baseline use of individual retinol supplements was associated with a significant reduction in melanoma risk (HR: 0.60, 95% CI: 0.41–0.89). High-dose (>1200 ug/day) supplemental retinol was also associated with reduced melanoma risk (HR: 0.74, 95% CI: 0.55–1.00), as compared to non-users. The reduction in melanoma risk was stronger in sun-exposed anatomic sites. There was no association of melanoma risk with dietary or total intake of vitamin A or carotenoids. Retinol supplementation may have a preventative role in melanoma among women. |
format | Online Article Text |
id | pubmed-3352977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
record_format | MEDLINE/PubMed |
spelling | pubmed-33529772012-12-01 Association of Vitamin A and Carotenoid Intake with Melanoma Risk in a Large Prospective Cohort Asgari, Maryam M. Brasky, Theodore M. White, Emily J Invest Dermatol Article Laboratory data suggest that intake of vitamin A and carotenoids, may have chemopreventive benefits against melanoma, but epidemiologic studies examining the association have yielded conflicting results. We examined whether dietary and supplemental vitamin A and carotenoid intake was associated with melanoma risk among 69,635 men and women who were participants of the Vitamins and Lifestyle (VITAL) cohort study in Western Washington. After an average of 5.84 years of follow-up, 566 incident melanomas were identified. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for risk of melanoma associated with dietary, supplement and total vitamin A and carotenoid intake after adjusting for melanoma risk factors. Baseline use of individual retinol supplements was associated with a significant reduction in melanoma risk (HR: 0.60, 95% CI: 0.41–0.89). High-dose (>1200 ug/day) supplemental retinol was also associated with reduced melanoma risk (HR: 0.74, 95% CI: 0.55–1.00), as compared to non-users. The reduction in melanoma risk was stronger in sun-exposed anatomic sites. There was no association of melanoma risk with dietary or total intake of vitamin A or carotenoids. Retinol supplementation may have a preventative role in melanoma among women. 2012-03-01 2012-06 /pmc/articles/PMC3352977/ /pubmed/22377763 http://dx.doi.org/10.1038/jid.2012.21 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Asgari, Maryam M. Brasky, Theodore M. White, Emily Association of Vitamin A and Carotenoid Intake with Melanoma Risk in a Large Prospective Cohort |
title | Association of Vitamin A and Carotenoid Intake with Melanoma Risk in a Large Prospective Cohort |
title_full | Association of Vitamin A and Carotenoid Intake with Melanoma Risk in a Large Prospective Cohort |
title_fullStr | Association of Vitamin A and Carotenoid Intake with Melanoma Risk in a Large Prospective Cohort |
title_full_unstemmed | Association of Vitamin A and Carotenoid Intake with Melanoma Risk in a Large Prospective Cohort |
title_short | Association of Vitamin A and Carotenoid Intake with Melanoma Risk in a Large Prospective Cohort |
title_sort | association of vitamin a and carotenoid intake with melanoma risk in a large prospective cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352977/ https://www.ncbi.nlm.nih.gov/pubmed/22377763 http://dx.doi.org/10.1038/jid.2012.21 |
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