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γδ T cells augment rejection of skin grafts by enhancing cross priming of CD8 T cells to skin derived antigen
γδ T cells possess innate like properties and are proposed to bridge the gap between innate and adaptive immunity. In this study we explored the role of γδ T cells in cutaneous immunity utilizing a skin transplantation model. Following engraftment of skin expressing cell associated model antigen (ov...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352982/ https://www.ncbi.nlm.nih.gov/pubmed/22358058 http://dx.doi.org/10.1038/jid.2012.16 |
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author | Rahimpour, Azad Mattarollo, Stephen R Yong, Michelle Leggatt, Graham R Steptoe, Raymond J Frazer, Ian H |
author_facet | Rahimpour, Azad Mattarollo, Stephen R Yong, Michelle Leggatt, Graham R Steptoe, Raymond J Frazer, Ian H |
author_sort | Rahimpour, Azad |
collection | PubMed |
description | γδ T cells possess innate like properties and are proposed to bridge the gap between innate and adaptive immunity. In this study we explored the role of γδ T cells in cutaneous immunity utilizing a skin transplantation model. Following engraftment of skin expressing cell associated model antigen (ovalbumin) in epithelial keratinocytes, skin resident γδ T cells enhanced graft rejection. While effector function of CD8 T cells was intact in the absence of γδ T cells, cross priming of CD8 T cell to graft derived antigen was impaired in the absence of γδ T cells. The reduced graft rejection and graft priming of γδ T cell deficient mice was evident in both acutely inflamed and well-healed grafting models. Furthermore, expression of the CD40 activation marker on migrating dendritic cells was lower in TCRδ-/- mice compared to wildtype mice, regardless of the presence or absence of inflammation associated with grafting. These results indicate that γδ T cells enhance graft priming and consequently the likelihood of a successful immune outcome in the context of skin graft rejection suggesting that γδ T cells may be an important component of immunity to epithelial cancers or infection. |
format | Online Article Text |
id | pubmed-3352982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
record_format | MEDLINE/PubMed |
spelling | pubmed-33529822012-12-01 γδ T cells augment rejection of skin grafts by enhancing cross priming of CD8 T cells to skin derived antigen Rahimpour, Azad Mattarollo, Stephen R Yong, Michelle Leggatt, Graham R Steptoe, Raymond J Frazer, Ian H J Invest Dermatol Article γδ T cells possess innate like properties and are proposed to bridge the gap between innate and adaptive immunity. In this study we explored the role of γδ T cells in cutaneous immunity utilizing a skin transplantation model. Following engraftment of skin expressing cell associated model antigen (ovalbumin) in epithelial keratinocytes, skin resident γδ T cells enhanced graft rejection. While effector function of CD8 T cells was intact in the absence of γδ T cells, cross priming of CD8 T cell to graft derived antigen was impaired in the absence of γδ T cells. The reduced graft rejection and graft priming of γδ T cell deficient mice was evident in both acutely inflamed and well-healed grafting models. Furthermore, expression of the CD40 activation marker on migrating dendritic cells was lower in TCRδ-/- mice compared to wildtype mice, regardless of the presence or absence of inflammation associated with grafting. These results indicate that γδ T cells enhance graft priming and consequently the likelihood of a successful immune outcome in the context of skin graft rejection suggesting that γδ T cells may be an important component of immunity to epithelial cancers or infection. 2012-02-23 2012-06 /pmc/articles/PMC3352982/ /pubmed/22358058 http://dx.doi.org/10.1038/jid.2012.16 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Rahimpour, Azad Mattarollo, Stephen R Yong, Michelle Leggatt, Graham R Steptoe, Raymond J Frazer, Ian H γδ T cells augment rejection of skin grafts by enhancing cross priming of CD8 T cells to skin derived antigen |
title | γδ T cells augment rejection of skin grafts by enhancing cross priming of CD8 T cells to skin derived antigen |
title_full | γδ T cells augment rejection of skin grafts by enhancing cross priming of CD8 T cells to skin derived antigen |
title_fullStr | γδ T cells augment rejection of skin grafts by enhancing cross priming of CD8 T cells to skin derived antigen |
title_full_unstemmed | γδ T cells augment rejection of skin grafts by enhancing cross priming of CD8 T cells to skin derived antigen |
title_short | γδ T cells augment rejection of skin grafts by enhancing cross priming of CD8 T cells to skin derived antigen |
title_sort | γδ t cells augment rejection of skin grafts by enhancing cross priming of cd8 t cells to skin derived antigen |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352982/ https://www.ncbi.nlm.nih.gov/pubmed/22358058 http://dx.doi.org/10.1038/jid.2012.16 |
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