Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities

The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,7:9,11-dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, wh...

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Autores principales: Torres, Eva, Duque, María D., López-Querol, Marta, Taylor, Martin C., Naesens, Lieve, Ma, Chunlong, Pinto, Lawrence H., Sureda, Francesc X., Kelly, John M., Vázquez, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. Published by Elsevier Ltd. 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353318/
https://www.ncbi.nlm.nih.gov/pubmed/22178660
http://dx.doi.org/10.1016/j.bmc.2011.11.050
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author Torres, Eva
Duque, María D.
López-Querol, Marta
Taylor, Martin C.
Naesens, Lieve
Ma, Chunlong
Pinto, Lawrence H.
Sureda, Francesc X.
Kelly, John M.
Vázquez, Santiago
author_facet Torres, Eva
Duque, María D.
López-Querol, Marta
Taylor, Martin C.
Naesens, Lieve
Ma, Chunlong
Pinto, Lawrence H.
Sureda, Francesc X.
Kelly, John M.
Vázquez, Santiago
author_sort Torres, Eva
collection PubMed
description The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,7:9,11-dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, while only one compound shows micromolar anti-influenza activity. The anti-influenza activity of this compound does not seem to be mediated by blocking of the M2 protein.
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spelling pubmed-33533182012-07-15 Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities Torres, Eva Duque, María D. López-Querol, Marta Taylor, Martin C. Naesens, Lieve Ma, Chunlong Pinto, Lawrence H. Sureda, Francesc X. Kelly, John M. Vázquez, Santiago Bioorg Med Chem Article The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,7:9,11-dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, while only one compound shows micromolar anti-influenza activity. The anti-influenza activity of this compound does not seem to be mediated by blocking of the M2 protein. Elsevier Ltd. Published by Elsevier Ltd. 2012-01-15 2011-12-01 /pmc/articles/PMC3353318/ /pubmed/22178660 http://dx.doi.org/10.1016/j.bmc.2011.11.050 Text en Copyright © 2011 Elsevier Ltd. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Torres, Eva
Duque, María D.
López-Querol, Marta
Taylor, Martin C.
Naesens, Lieve
Ma, Chunlong
Pinto, Lawrence H.
Sureda, Francesc X.
Kelly, John M.
Vázquez, Santiago
Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities
title Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities
title_full Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities
title_fullStr Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities
title_full_unstemmed Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities
title_short Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities
title_sort synthesis of benzopolycyclic cage amines: nmda receptor antagonist, trypanocidal and antiviral activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353318/
https://www.ncbi.nlm.nih.gov/pubmed/22178660
http://dx.doi.org/10.1016/j.bmc.2011.11.050
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