Cargando…

Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities

The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,7:9,11-dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, wh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Torres, Eva, Duque, María D., López-Querol, Marta, Taylor, Martin C., Naesens, Lieve, Ma, Chunlong, Pinto, Lawrence H., Sureda, Francesc X., Kelly, John M., Vázquez, Santiago
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. Published by Elsevier Ltd. 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353318/ https://www.ncbi.nlm.nih.gov/pubmed/22178660 http://dx.doi.org/10.1016/j.bmc.2011.11.050

Ejemplares similares

Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines
por: Duque, María D., et al.
Publicado: (2009)

Role of the viral hemagglutinin in the anti-influenza virus activity of newly synthesized polycyclic amine compounds
por: Torres, Eva, et al.
Publicado: (2013)

Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog
por: Leiva, Rosana, et al.
Publicado: (2015)

Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7–NMDA Receptor Antagonists
por: Karoutzou, Olga, et al.
Publicado: (2018)

Enantiopure Indolo[2,3-a]quinolizidines: Synthesis and Evaluation as NMDA Receptor Antagonists
por: Pereira, Nuno A. L., et al.
Publicado: (2016)

Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs
por: Camps, Pelayo, et al.
Publicado: (2008)

Easily Accessible Polycyclic Amines that Inhibit the Wild-Type and Amantadine-Resistant Mutants of the M2 Channel of Influenza A Virus
por: Rey-Carrizo, Matias, et al.
Publicado: (2014)

Editorial overview: Antiviral strategies: Antiviral drug design: creating new ideas against old and new bugs
por: Naesens, Lieve, et al.
Publicado: (2017)

The Trypanocidal Activity of Naphthoquinones: A Review
por: Ventura Pinto, Antônio, et al.
Publicado: (2009)

The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design
por: Stevaert, Annelies, et al.
Publicado: (2016)

Novel Lipophilic Hydroxamates Based on Spirocarbocyclic Hydantoin Scaffolds with Potent Antiviral and Trypanocidal Activity
por: Pardali, Vasiliki, et al.
Publicado: (2023)

An In Vitro Assay for Trypanocidal Activity
por: Rubin, Benjamin Arnold
Publicado: (1948)

Trypanocidal Activity of Flavanone Derivatives
por: Maciel Diogo, Gabriela, et al.
Publicado: (2020)

Biogenic trypanocidal sesquiterpenes: lead compounds to design future trypanocidal drugs - a mini review
por: Saeidnia, Soodabeh, et al.
Publicado: (2013)

NMDA Receptor Antagonists for Treatment of Depression
por: Ates-Alagoz, Zeynep, et al.
Publicado: (2013)

The Trypanocidal Effect of Antibiotic Lactones and of their Analogs
por: Rubin, Benjamin Arnold
Publicado: (1948)

Quinol derivatives as potential trypanocidal agents
por: Capes, Amy, et al.
Publicado: (2012)

Trypanocidal Activity of Marine Natural Products
por: Jones, Amy J., et al.
Publicado: (2013)

Trypanocidal Essential Oils: A Review
por: de Morais, Mayara Castro, et al.
Publicado: (2020)

Insights into Ergosterol Peroxide’s Trypanocidal Activity
por: Meza-Menchaca, Thuluz, et al.
Publicado: (2019)

Trypanocidal and leishmanicidal activity of six limonoids
por: Steverding, Dietmar, et al.
Publicado: (2020)

An Update on African Trypanocide Pharmaceutics and Resistance
por: Kasozi, Keneth Iceland, et al.
Publicado: (2022)

Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure
por: Gawin, Rafał, et al.
Publicado: (2008)

Allosteric antagonist action at triheteromeric NMDA receptors
por: Gibb, Alasdair J.
Publicado: (2022)

Synthesis and antiviral properties of novel indole-based thiosemicarbazides and 4-thiazolidinones
por: Cihan-Üstündağ, Gökçe, et al.
Publicado: (2016)

Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin
por: Derudas, Marco, et al.
Publicado: (2010)

Glial cell reactivity and oxidative stress prevention in Alzheimer’s disease mice model by an optimized NMDA receptor antagonist
por: Companys-Alemany, Júlia, et al.
Publicado: (2022)

Design and synthesis of novel Imidazo[2,1-b]thiazole derivatives as potent antiviral and antimycobacterial agents
por: Gürsoy, Elif, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory Viruses
por: Francesconi, Valeria, et al.
Publicado: (2020)

A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice
por: Companys-Alemany, Júlia, et al.
Publicado: (2020)

Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function
por: Reeve, James E., et al.
Publicado: (2012)

Anti-oxidative trypanocidal drugs, myth or reality
por: Saeidnia, Soodabeh
Publicado: (2013)

Characterization and Trypanocidal Activity of a Novel Pyranaphthoquinone
por: Dantas, Elen Diana, et al.
Publicado: (2017)

Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
por: Legarda-Ceballos, Ana L., et al.
Publicado: (2015)

Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs
por: Giordani, Federica, et al.
Publicado: (2020)

In Vitro and In Vivo Trypanocidal Efficacy of Nitrofuryl- and Nitrothienylazines
por: Janse van Rensburg, Helena D., et al.
Publicado: (2023)

Synthesis of Antiviral Perfluoroalkyl Derivatives of Teicoplanin and Vancomycin
por: Bereczki, Ilona, et al.
Publicado: (2020)

Design, synthesis, antitubercular and antiviral properties of new spirocyclic indole derivatives
por: Cihan-Üstündağ, Gökçe, et al.
Publicado: (2019)

Reprogramming of the Antibacterial Drug Vancomycin Results in Potent Antiviral Agents Devoid of Antibacterial Activity
por: Szűcs, Zsolt, et al.
Publicado: (2020)

Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae)
por: Quintero, Wendy Lorena, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0pjg4i3o6gd9680sbcki1g39qk