Fluorescence Correlation Spectroscopy in Drug Discovery: Study of Alexa532-Endothelin 1 Binding to the Endothelin ET(A) Receptor to Describe the Pharmacological Profile of Natural Products

Fluorescence correlation spectroscopy and the newly synthesized Alexa532-ET1 were used to study the dynamics of the endothelin ET(A) receptor-ligand complex alone and under the influence of a semisynthetic selective antagonist and a fungal extract on living A10 cells. Dose-dependent increase of inos...

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Detalles Bibliográficos
Autores principales: Caballero-George, Catherina, Sorkalla, Thomas, Jakobs, Daniel, Bolaños, Jessica, Raja, Huzefa, Shearer, Carol, Bermingham, Eldredge, Häberlein, Hanns
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353486/
https://www.ncbi.nlm.nih.gov/pubmed/22623909
http://dx.doi.org/10.1100/2012/524169

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