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Macular Retinal and Nerve Fiber Layer Thickness in Early Glaucoma: Clinical Correlations

PURPOSE: Previous studies have evaluated macular retinal thickness (RT) and nerve fiber layer thickness (RNFLT) changes in early glaucoma using elaborate optical coherence tomography (OCT) scanning protocols. MATERIALS AND METHODS: This study examines RT and RNFLT using standard scanning protocols i...

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Autores principales: Arvanitaki, Vassiliki, Tsilimbaris, Miltiadis K., Pallikaris, Aristofanis, Moschandreas, Ioanna, Minos, Evangelos, Pallikaris, Ioannis G., Detorakis, Efstathios T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353669/
https://www.ncbi.nlm.nih.gov/pubmed/22623860
http://dx.doi.org/10.4103/0974-9233.95251
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author Arvanitaki, Vassiliki
Tsilimbaris, Miltiadis K.
Pallikaris, Aristofanis
Moschandreas, Ioanna
Minos, Evangelos
Pallikaris, Ioannis G.
Detorakis, Efstathios T.
author_facet Arvanitaki, Vassiliki
Tsilimbaris, Miltiadis K.
Pallikaris, Aristofanis
Moschandreas, Ioanna
Minos, Evangelos
Pallikaris, Ioannis G.
Detorakis, Efstathios T.
author_sort Arvanitaki, Vassiliki
collection PubMed
description PURPOSE: Previous studies have evaluated macular retinal thickness (RT) and nerve fiber layer thickness (RNFLT) changes in early glaucoma using elaborate optical coherence tomography (OCT) scanning protocols. MATERIALS AND METHODS: This study examines RT and RNFLT using standard scanning protocols in early glaucoma. In this prospective, nonrandomized case series, 95 eyes of 95 patients were evaluated, including 29 nonglaucomatous subjects (control group), 34 glaucoma suspects, and 32 early manifest glaucoma patients. RT and RNFLT were measured using scanning fast macular thickness map and Fast RNFLT (3.4) protocols on a 1.70 mm radius around the macular center (respectively) in all four quadrants. The fast RNFLT (3.4) protocol was transposed on the macula from the peri-papillary area. Data were statistically analyzed for differences between groups, and for correlations between parameters. P<0.5 was statistically significant. RESULTS: Both early manifest glaucoma patients and glaucoma suspects had significantly lower RT than controls in all quadrants. RNFLT differences in all quadrants were not statistically significant (P>0.05). RT was significantly inversely correlated with axial length in early manifest glaucoma patients and glaucoma suspects but not in controls. CONCLUSIONS: The finding that RT was significantly lower in early manifest glaucoma patients and glaucoma suspects indicates that the transposition of the OCT fast RNFL thickness (3.4) protocol from the peri-papillary area to the peri-macular area can be used for early glaucoma diagnosis. Intraretinal changes in early glaucoma, likely precede nerve fiber changes.
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spelling pubmed-33536692012-05-23 Macular Retinal and Nerve Fiber Layer Thickness in Early Glaucoma: Clinical Correlations Arvanitaki, Vassiliki Tsilimbaris, Miltiadis K. Pallikaris, Aristofanis Moschandreas, Ioanna Minos, Evangelos Pallikaris, Ioannis G. Detorakis, Efstathios T. Middle East Afr J Ophthalmol Original Article PURPOSE: Previous studies have evaluated macular retinal thickness (RT) and nerve fiber layer thickness (RNFLT) changes in early glaucoma using elaborate optical coherence tomography (OCT) scanning protocols. MATERIALS AND METHODS: This study examines RT and RNFLT using standard scanning protocols in early glaucoma. In this prospective, nonrandomized case series, 95 eyes of 95 patients were evaluated, including 29 nonglaucomatous subjects (control group), 34 glaucoma suspects, and 32 early manifest glaucoma patients. RT and RNFLT were measured using scanning fast macular thickness map and Fast RNFLT (3.4) protocols on a 1.70 mm radius around the macular center (respectively) in all four quadrants. The fast RNFLT (3.4) protocol was transposed on the macula from the peri-papillary area. Data were statistically analyzed for differences between groups, and for correlations between parameters. P<0.5 was statistically significant. RESULTS: Both early manifest glaucoma patients and glaucoma suspects had significantly lower RT than controls in all quadrants. RNFLT differences in all quadrants were not statistically significant (P>0.05). RT was significantly inversely correlated with axial length in early manifest glaucoma patients and glaucoma suspects but not in controls. CONCLUSIONS: The finding that RT was significantly lower in early manifest glaucoma patients and glaucoma suspects indicates that the transposition of the OCT fast RNFL thickness (3.4) protocol from the peri-papillary area to the peri-macular area can be used for early glaucoma diagnosis. Intraretinal changes in early glaucoma, likely precede nerve fiber changes. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3353669/ /pubmed/22623860 http://dx.doi.org/10.4103/0974-9233.95251 Text en Copyright: © Middle East African Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Arvanitaki, Vassiliki
Tsilimbaris, Miltiadis K.
Pallikaris, Aristofanis
Moschandreas, Ioanna
Minos, Evangelos
Pallikaris, Ioannis G.
Detorakis, Efstathios T.
Macular Retinal and Nerve Fiber Layer Thickness in Early Glaucoma: Clinical Correlations
title Macular Retinal and Nerve Fiber Layer Thickness in Early Glaucoma: Clinical Correlations
title_full Macular Retinal and Nerve Fiber Layer Thickness in Early Glaucoma: Clinical Correlations
title_fullStr Macular Retinal and Nerve Fiber Layer Thickness in Early Glaucoma: Clinical Correlations
title_full_unstemmed Macular Retinal and Nerve Fiber Layer Thickness in Early Glaucoma: Clinical Correlations
title_short Macular Retinal and Nerve Fiber Layer Thickness in Early Glaucoma: Clinical Correlations
title_sort macular retinal and nerve fiber layer thickness in early glaucoma: clinical correlations
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353669/
https://www.ncbi.nlm.nih.gov/pubmed/22623860
http://dx.doi.org/10.4103/0974-9233.95251
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