Development of 4H-pyridopyrimidines: a class of selective bacterial protein synthesis inhibitors

BACKGROUND: We have identified a series of compounds that inhibit protein synthesis in bacteria. Initial IC(50)'s in aminoacylation/translation (A/T) assays ranged from 3 to14 μM. This series of compounds are variations on a 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol scaffold (e.g., 4H-pyrid...

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Detalles Bibliográficos
Autores principales: Guiles, Joseph W, Toro, Andras, Ochsner, Urs A, Bullard, James M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2012
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353862/
https://www.ncbi.nlm.nih.gov/pubmed/22373064
http://dx.doi.org/10.1186/2191-2858-2-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353862/
https://www.ncbi.nlm.nih.gov/pubmed/22373064
http://dx.doi.org/10.1186/2191-2858-2-5

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