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Development of 4H-pyridopyrimidines: a class of selective bacterial protein synthesis inhibitors
BACKGROUND: We have identified a series of compounds that inhibit protein synthesis in bacteria. Initial IC(50)'s in aminoacylation/translation (A/T) assays ranged from 3 to14 μM. This series of compounds are variations on a 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol scaffold (e.g., 4H-pyrid...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353862/ https://www.ncbi.nlm.nih.gov/pubmed/22373064 http://dx.doi.org/10.1186/2191-2858-2-5 |