Caspase Inhibition with XIAP as an Adjunct to AAV Vector Gene-Replacement Therapy: Improving Efficacy and Prolonging the Treatment Window

PURPOSE: AAV-mediated gene therapy in the rd10 mouse, with retinal degeneration caused by mutation in the rod cyclic guanosine monophosphate phosphodiesterase β-subunit (PDEβ) gene, produces significant, but transient, rescue of photoreceptor structure and function. This study evaluates the ability...

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Detalles Bibliográficos
Autores principales: Yao, Jingyu, Jia, Lin, Khan, Naheed, Zheng, Qiong-Duan, Moncrief, Ashley, Hauswirth, William W., Thompson, Debra A., Zacks, David N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353899/
https://www.ncbi.nlm.nih.gov/pubmed/22615940
http://dx.doi.org/10.1371/journal.pone.0037197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353899/
https://www.ncbi.nlm.nih.gov/pubmed/22615940
http://dx.doi.org/10.1371/journal.pone.0037197

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