Cargando…

Caspase Inhibition with XIAP as an Adjunct to AAV Vector Gene-Replacement Therapy: Improving Efficacy and Prolonging the Treatment Window

PURPOSE: AAV-mediated gene therapy in the rd10 mouse, with retinal degeneration caused by mutation in the rod cyclic guanosine monophosphate phosphodiesterase β-subunit (PDEβ) gene, produces significant, but transient, rescue of photoreceptor structure and function. This study evaluates the ability...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yao, Jingyu, Jia, Lin, Khan, Naheed, Zheng, Qiong-Duan, Moncrief, Ashley, Hauswirth, William W., Thompson, Debra A., Zacks, David N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353899/ https://www.ncbi.nlm.nih.gov/pubmed/22615940 http://dx.doi.org/10.1371/journal.pone.0037197

Ejemplares similares

Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis
por: Potts, Patrick Ryan, et al.
Publicado: (2003)

XIAP-mediated Caspase Inhibition in Hodgkin's Lymphoma–derived B Cells
por: Kashkar, Hamid, et al.
Publicado: (2003)

Caspase-3, Caspase-8 and XIAP Gene Expression in the Placenta: Exploring the Causes of Spontaneous Preterm Labour
por: Belousova, Vera, et al.
Publicado: (2023)

AAV retinal transduction in a large animal model species: Comparison of a self-complementary AAV2/5 with a single-stranded AAV2/5 vector
por: Petersen-Jones, S.M., et al.
Publicado: (2009)

Gene therapy following subretinal AAV5 vector delivery is not affected by a previous intravitreal AAV5 vector administration in the partner eye
por: Li, Wensheng, et al.
Publicado: (2009)

Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9
por: Ekert, Paul G., et al.
Publicado: (2001)

The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3– and caspase 9–interacting sites
por: Silke, John, et al.
Publicado: (2002)

FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function
por: Coccia, Elena, et al.
Publicado: (2022)

XIAP Protection of Photoreceptors in Animal Models of Retinitis Pigmentosa
por: Leonard, Kevin C., et al.
Publicado: (2007)

Innate Immune Responses to AAV Vectors
por: Rogers, Geoffrey L., et al.
Publicado: (2011)

Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential
por: Li, Qiuhong, et al.
Publicado: (2008)

T Cell-Mediated Immune Responses to AAV and AAV Vectors
por: Ertl, Hildegund C. J.
Publicado: (2021)

Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach
por: Mowat, FM, et al.
Publicado: (2013)

Quantifying transduction efficiencies of unmodified and tyrosine capsid mutant AAV vectors in vitro using two ocular cell lines
por: Ryals, Renee C., et al.
Publicado: (2011)

AAV-8 and AAV-9 Vectors Cooperate with Serum Proteins Differently Than AAV-1 and AAV-6
por: Denard, Jérôme, et al.
Publicado: (2018)

AAV6 as an effective gene delivery vector for prolonged transgene expression in intervertebral disc cells in vivo
por: Kim, Chi Heon, et al.
Publicado: (2020)

Immune Response Mechanisms against AAV Vectors in Animal Models
por: Martino, Ashley T., et al.
Publicado: (2019)

Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy
por: Rodríguez-Berriguete, Gonzalo, et al.
Publicado: (2015)

BB-301: a silence and replace AAV-based vector for the treatment of oculopharyngeal muscular dystrophy
por: Strings-Ufombah, Vanessa, et al.
Publicado: (2021)

The long noncoding RNA XIAP-AS1 promotes XIAP transcription by XIAP-AS1 interacting with Sp1 in gastric cancer cells
por: Cai, Jun, et al.
Publicado: (2017)

Syngeneic AAV Pseudo-particles Potentiate Gene Transduction of AAV Vectors
por: Wang, Qizhao, et al.
Publicado: (2016)

Targeting Photoreceptors via Intravitreal Delivery Using Novel, Capsid-Mutated AAV Vectors
por: Kay, Christine N., et al.
Publicado: (2013)

AAV Vectored Immunoprophylaxis for Filovirus Infections
por: Rghei, Amira D., et al.
Publicado: (2020)

AAV gene therapy vectors in the TMJ
por: Brouxhon, Sabine M., et al.
Publicado: (2022)

Targeting the somatosensory system with AAV9 and AAV2retro viral vectors
por: Skorput, Alexander G. J., et al.
Publicado: (2022)

Targeting the Root Cause of Mucopolysaccharidosis IIIA with a New scAAV9 Gene Replacement Vector
por: Bobo, Tierra A., et al.
Publicado: (2020)

Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium
por: Dharmapatni, Anak ASSK, et al.
Publicado: (2009)

α-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3
por: Fang, Dongmei, et al.
Publicado: (2019)

Recent Advancements in AAV-Vectored Immunoprophylaxis in the Nonhuman Primate Model
por: Campbell, Elena S. B., et al.
Publicado: (2023)

Correction: Targeting Photoreceptors via Intravitreal Delivery Using Novel, Capsid-Mutated AAV Vectors
por: Kay, Christine N., et al.
Publicado: (2013)

Intratumoral Decorin Gene Delivery by AAV Vector Inhibits Brain Glioblastomas and Prolongs Survival of Animals by Inducing Cell Differentiation
por: Ma, Hsin-I, et al.
Publicado: (2014)

XIAP’s Profile in Human Cancer
por: Tu, Huailu, et al.
Publicado: (2020)

Near-perfect infectivity of wild-type AAV as benchmark for infectivity of recombinant AAV vectors
por: Zeltner, Nadja, et al.
Publicado: (2010)

Successful Transduction with AAV Vectors after Selective Depletion of Anti-AAV Antibodies by Immunoadsorption
por: Orlowski, Alejandro, et al.
Publicado: (2020)

XIAP Antagonist Embelin Inhibited Proliferation of Cholangiocarcinoma Cells
por: Wehrkamp, Cody J., et al.
Publicado: (2014)

Pre-Clinical Assessment of Immune Responses to Adeno-Associated Virus (AAV) Vectors
por: Basner-Tschakarjan, Etiena, et al.
Publicado: (2014)

Downregulation of GRP78 and XIAP is correlated with apoptosis during cerulein-induced acute pancreatitis in rats via regulation of caspase activation
por: LIU, YONG, et al.
Publicado: (2012)

Interplay between Caspase 9 and X-linked Inhibitor of Apoptosis Protein (XIAP) in the oocyte elimination during fetal mouse development
por: Liu, Xueqing, et al.
Publicado: (2019)

Retraction: α-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3
por: Fang, Dongmei, et al.
Publicado: (2022)

AAV Vectors Vaccines Against Infectious Diseases
por: Nieto, Karen, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_hr66hj5ndo35jqh9287co80tdp