A Significant but Rather Mild Contribution of T286 Autophosphorylation to Ca(2+)/CaM-Stimulated CaMKII Activity

BACKGROUND: Autophosphorylation of the Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) at T286 generates partially Ca(2+)/CaM-independent “autonomous” activity, which is thought to be required for long-term potentiation (LTP), a form of synaptic plasticity thought to underlie learning a...

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Detalles Bibliográficos
Autores principales: Coultrap, Steven J., Barcomb, Kelsey, Bayer, K. Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353915/
https://www.ncbi.nlm.nih.gov/pubmed/22615928
http://dx.doi.org/10.1371/journal.pone.0037176

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