The Loss of Functional Caspase-12 in Europe Is a Pre-Neolithic Event

BACKGROUND: Caspase-12 (CASP12) modulates the susceptibility to sepsis. In humans, the “C” allele at CASP12 rs497116 has been associated with an increased risk of sepsis. Instead, the derived “T” allele encodes for an inactive caspase-12. Interestingly, Eurasians are practically fixed for the inacti...

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Detalles Bibliográficos
Autores principales: Hervella, Montserrat, Plantinga, Theo S., Alonso, Santos, Ferwerda, Bart, Izagirre, Neskuts, Fontecha, Lara, Fregel, Rosa, van der Meer, Jos W. M., de-la-Rúa, Concepcion, Netea, Mihai G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353979/
https://www.ncbi.nlm.nih.gov/pubmed/22615879
http://dx.doi.org/10.1371/journal.pone.0037022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353979/
https://www.ncbi.nlm.nih.gov/pubmed/22615879
http://dx.doi.org/10.1371/journal.pone.0037022

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