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Transformation of Synthetic Allicin: The Influence of Ultrasound, Microwaves, Different Solvents and Temperatures, and the Products Isolation
The transformation of the synthesized allicin, using conventional method, the influence of ultrasound and microwaves, in different organic solvents (acetonitrile, acetone, methanol, and chloroform), at various temperatures (room temperature, 45°C, and 55°C) was investigated. Allicin degradation kine...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Scientific World Journal
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354368/ https://www.ncbi.nlm.nih.gov/pubmed/22629145 http://dx.doi.org/10.1100/2012/561823 |
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author | Ilić, Dušica Nikolić, Vesna Stanković, Mihajlo Nikolić, Ljubiša Stanojević, Ljiljana Mladenović-Ranisavljević, Ivana Šmelcerović, Andrija |
author_facet | Ilić, Dušica Nikolić, Vesna Stanković, Mihajlo Nikolić, Ljubiša Stanojević, Ljiljana Mladenović-Ranisavljević, Ivana Šmelcerović, Andrija |
author_sort | Ilić, Dušica |
collection | PubMed |
description | The transformation of the synthesized allicin, using conventional method, the influence of ultrasound and microwaves, in different organic solvents (acetonitrile, acetone, methanol, and chloroform), at various temperatures (room temperature, 45°C, and 55°C) was investigated. Allicin degradation kinetic was monitored by HPLC. Allicin transformation under the effect of microwaves is faster than transformations performed under the influence of ultrasound or by conventional method. Increase of the temperature accelerates allicin transformation. Pharmacologically active compounds of (E)-ajoene, (Z)-ajoene, 3-vinyl-4H-1,2-dithiin, 2-vinyl-4H-1,3-dithiin, and diallyl disulfide were isolated from the mixture of transformation products of allicin under the influence of microwaves in methanol at 55°C, which is according to kinetic parameters (highest values of the order of reaction and the lowest activation energy) the optimal method. |
format | Online Article Text |
id | pubmed-3354368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Scientific World Journal |
record_format | MEDLINE/PubMed |
spelling | pubmed-33543682012-05-24 Transformation of Synthetic Allicin: The Influence of Ultrasound, Microwaves, Different Solvents and Temperatures, and the Products Isolation Ilić, Dušica Nikolić, Vesna Stanković, Mihajlo Nikolić, Ljubiša Stanojević, Ljiljana Mladenović-Ranisavljević, Ivana Šmelcerović, Andrija ScientificWorldJournal Research Article The transformation of the synthesized allicin, using conventional method, the influence of ultrasound and microwaves, in different organic solvents (acetonitrile, acetone, methanol, and chloroform), at various temperatures (room temperature, 45°C, and 55°C) was investigated. Allicin degradation kinetic was monitored by HPLC. Allicin transformation under the effect of microwaves is faster than transformations performed under the influence of ultrasound or by conventional method. Increase of the temperature accelerates allicin transformation. Pharmacologically active compounds of (E)-ajoene, (Z)-ajoene, 3-vinyl-4H-1,2-dithiin, 2-vinyl-4H-1,3-dithiin, and diallyl disulfide were isolated from the mixture of transformation products of allicin under the influence of microwaves in methanol at 55°C, which is according to kinetic parameters (highest values of the order of reaction and the lowest activation energy) the optimal method. The Scientific World Journal 2012-05-02 /pmc/articles/PMC3354368/ /pubmed/22629145 http://dx.doi.org/10.1100/2012/561823 Text en Copyright © 2012 Dušica Ilić et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ilić, Dušica Nikolić, Vesna Stanković, Mihajlo Nikolić, Ljubiša Stanojević, Ljiljana Mladenović-Ranisavljević, Ivana Šmelcerović, Andrija Transformation of Synthetic Allicin: The Influence of Ultrasound, Microwaves, Different Solvents and Temperatures, and the Products Isolation |
title | Transformation of Synthetic Allicin: The Influence of Ultrasound, Microwaves, Different Solvents and Temperatures, and the Products Isolation |
title_full | Transformation of Synthetic Allicin: The Influence of Ultrasound, Microwaves, Different Solvents and Temperatures, and the Products Isolation |
title_fullStr | Transformation of Synthetic Allicin: The Influence of Ultrasound, Microwaves, Different Solvents and Temperatures, and the Products Isolation |
title_full_unstemmed | Transformation of Synthetic Allicin: The Influence of Ultrasound, Microwaves, Different Solvents and Temperatures, and the Products Isolation |
title_short | Transformation of Synthetic Allicin: The Influence of Ultrasound, Microwaves, Different Solvents and Temperatures, and the Products Isolation |
title_sort | transformation of synthetic allicin: the influence of ultrasound, microwaves, different solvents and temperatures, and the products isolation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354368/ https://www.ncbi.nlm.nih.gov/pubmed/22629145 http://dx.doi.org/10.1100/2012/561823 |
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