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Endemic pemphigus foliaceus over a century: Part I

BACKGROUND: Endemic pemphigus foliaceus (EPF) is the only known autoimmune disease presenting in circumscribed geographic areas. AIM: We aim to provide information concerning the natural course of EPF, including systemic compromise in the presteroid era, which has been largely unavailable in the cur...

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Autores principales: Abréu-Vélez, Ana María, Reason, Iara J. de Messias, Howard, Michael S., Roselino, Ana Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354435/
https://www.ncbi.nlm.nih.gov/pubmed/22624115
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author Abréu-Vélez, Ana María
Reason, Iara J. de Messias
Howard, Michael S.
Roselino, Ana Maria
author_facet Abréu-Vélez, Ana María
Reason, Iara J. de Messias
Howard, Michael S.
Roselino, Ana Maria
author_sort Abréu-Vélez, Ana María
collection PubMed
description BACKGROUND: Endemic pemphigus foliaceus (EPF) is the only known autoimmune disease presenting in circumscribed geographic areas. AIM: We aim to provide information concerning the natural course of EPF, including systemic compromise in the presteroid era, which has been largely unavailable in the current medical literature. MATERIAL & METHODS: By a retrospective review of the literature we aim to compile and compare the focus of EPF and the current knowledge about them. The main aim of this review is to summarize our current knowledge of EPF, including data described almost one century ago; and, to include several unindexed reports, which may have not been available to many current scientists and health care personnel. RESULTS: Foci of EPF have been described in several Central American and South American countries, affecting predominately young people and Amerindians, with an additional female predilection. Although most cases have occurred in Brazil, some cases have been reported in Peru, Paraguay, El Salvador, and Venezuela. Another variant of EPF has been described in El Bagre, Colombia, affecting older men and a few post-menopausal females. Finally, another type of EPF was described in nomadic tribes affecting females of child bearing age in Tunisia, Africa. CONCLUSION: Our understanding of EPF has been hampered by a lack of government attention to these diseases, especially in some South and Central American countries. Other factors that have made past studies of EPF difficult include 1) that the disease foci are often located in rural areas bordering the rain forest of underdeveloped countries; and 2) military conflicts in some of these areas.
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spelling pubmed-33544352012-05-23 Endemic pemphigus foliaceus over a century: Part I Abréu-Vélez, Ana María Reason, Iara J. de Messias Howard, Michael S. Roselino, Ana Maria N Am J Med Sci Review Article BACKGROUND: Endemic pemphigus foliaceus (EPF) is the only known autoimmune disease presenting in circumscribed geographic areas. AIM: We aim to provide information concerning the natural course of EPF, including systemic compromise in the presteroid era, which has been largely unavailable in the current medical literature. MATERIAL & METHODS: By a retrospective review of the literature we aim to compile and compare the focus of EPF and the current knowledge about them. The main aim of this review is to summarize our current knowledge of EPF, including data described almost one century ago; and, to include several unindexed reports, which may have not been available to many current scientists and health care personnel. RESULTS: Foci of EPF have been described in several Central American and South American countries, affecting predominately young people and Amerindians, with an additional female predilection. Although most cases have occurred in Brazil, some cases have been reported in Peru, Paraguay, El Salvador, and Venezuela. Another variant of EPF has been described in El Bagre, Colombia, affecting older men and a few post-menopausal females. Finally, another type of EPF was described in nomadic tribes affecting females of child bearing age in Tunisia, Africa. CONCLUSION: Our understanding of EPF has been hampered by a lack of government attention to these diseases, especially in some South and Central American countries. Other factors that have made past studies of EPF difficult include 1) that the disease foci are often located in rural areas bordering the rain forest of underdeveloped countries; and 2) military conflicts in some of these areas. Medknow Publications & Media Pvt Ltd 2010-02 /pmc/articles/PMC3354435/ /pubmed/22624115 Text en Copyright: © North American Journal of Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Abréu-Vélez, Ana María
Reason, Iara J. de Messias
Howard, Michael S.
Roselino, Ana Maria
Endemic pemphigus foliaceus over a century: Part I
title Endemic pemphigus foliaceus over a century: Part I
title_full Endemic pemphigus foliaceus over a century: Part I
title_fullStr Endemic pemphigus foliaceus over a century: Part I
title_full_unstemmed Endemic pemphigus foliaceus over a century: Part I
title_short Endemic pemphigus foliaceus over a century: Part I
title_sort endemic pemphigus foliaceus over a century: part i
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354435/
https://www.ncbi.nlm.nih.gov/pubmed/22624115
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