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Podocyte GTPases regulate kidney filter dynamics

The way we are thinking about the kidney filtration barrier is changing from that of a static sieve into a highly dynamic structure regulated through the motility of podocyte foot processes. It has been shown in vitro that inactivation of the small GTPase RhoA causes hypermotility, whereas activatio...

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Detalles Bibliográficos
Autores principales: Kistler, Andreas D., Altintas, Mehmet M., Reiser, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354621/
https://www.ncbi.nlm.nih.gov/pubmed/22584591
http://dx.doi.org/10.1038/ki.2012.12
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author Kistler, Andreas D.
Altintas, Mehmet M.
Reiser, Jochen
author_facet Kistler, Andreas D.
Altintas, Mehmet M.
Reiser, Jochen
author_sort Kistler, Andreas D.
collection PubMed
description The way we are thinking about the kidney filtration barrier is changing from that of a static sieve into a highly dynamic structure regulated through the motility of podocyte foot processes. It has been shown in vitro that inactivation of the small GTPase RhoA causes hypermotility, whereas activation decreases motility. The current article by Wang et al. now shows that both, RhoA over- and underactivation, lead to podocyte foot process effacement and proteinuria in vivo. These data suggest that podocyte health requires a well-controlled balance between the two extremes.
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spelling pubmed-33546212012-12-01 Podocyte GTPases regulate kidney filter dynamics Kistler, Andreas D. Altintas, Mehmet M. Reiser, Jochen Kidney Int Article The way we are thinking about the kidney filtration barrier is changing from that of a static sieve into a highly dynamic structure regulated through the motility of podocyte foot processes. It has been shown in vitro that inactivation of the small GTPase RhoA causes hypermotility, whereas activation decreases motility. The current article by Wang et al. now shows that both, RhoA over- and underactivation, lead to podocyte foot process effacement and proteinuria in vivo. These data suggest that podocyte health requires a well-controlled balance between the two extremes. 2012-06 /pmc/articles/PMC3354621/ /pubmed/22584591 http://dx.doi.org/10.1038/ki.2012.12 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Kistler, Andreas D.
Altintas, Mehmet M.
Reiser, Jochen
Podocyte GTPases regulate kidney filter dynamics
title Podocyte GTPases regulate kidney filter dynamics
title_full Podocyte GTPases regulate kidney filter dynamics
title_fullStr Podocyte GTPases regulate kidney filter dynamics
title_full_unstemmed Podocyte GTPases regulate kidney filter dynamics
title_short Podocyte GTPases regulate kidney filter dynamics
title_sort podocyte gtpases regulate kidney filter dynamics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354621/
https://www.ncbi.nlm.nih.gov/pubmed/22584591
http://dx.doi.org/10.1038/ki.2012.12
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