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CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population

Background. Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. Our previous studies showed expression of CD40 ligand on CD4+ T cells correlated to the coronary artery lesion (CAL) and disease progress in KD. Other studies from Japan suggested the role of CD40L in the...

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Autores principales: Kuo, Ho-Chang, Chao, Mei-Chyn, Hsu, Yu-Wen, Lin, Ying-Chi, Huang, Ying-Hsien, Yu, Hong-Ren, Hou, Ming-Feng, Liang, Chi-Di, Yang, Kuender D., Chang, Wei-Chiao, Wang, Chih-Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354684/
https://www.ncbi.nlm.nih.gov/pubmed/22645426
http://dx.doi.org/10.1100/2012/520865
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author Kuo, Ho-Chang
Chao, Mei-Chyn
Hsu, Yu-Wen
Lin, Ying-Chi
Huang, Ying-Hsien
Yu, Hong-Ren
Hou, Ming-Feng
Liang, Chi-Di
Yang, Kuender D.
Chang, Wei-Chiao
Wang, Chih-Lu
author_facet Kuo, Ho-Chang
Chao, Mei-Chyn
Hsu, Yu-Wen
Lin, Ying-Chi
Huang, Ying-Hsien
Yu, Hong-Ren
Hou, Ming-Feng
Liang, Chi-Di
Yang, Kuender D.
Chang, Wei-Chiao
Wang, Chih-Lu
author_sort Kuo, Ho-Chang
collection PubMed
description Background. Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. Our previous studies showed expression of CD40 ligand on CD4+ T cells correlated to the coronary artery lesion (CAL) and disease progress in KD. Other studies from Japan suggested the role of CD40L in the pathogenesis of CAL, and this might help explain the excessive number of males affected with KD but cannot be reproduced by Taiwanese population. This study was conducted to investigate the CD40 polymorphism in KD and CAL formation. Methods. A total of 950 subjects (381 KD patients and 569 controls) were investigated to identify 2 tagging single-nucleotide polymorphisms (tSNPs) of CD40 (rs4810485 and rs1535045) by using the TaqMan allelic discrimination assay. Results. A significant association was noted with regards to CD40 tSNPs (rs1535045) between controls and KD patients (P = 0.0405, dominant model). In KD patients, polymorphisms of CD40 (rs4810485) showed significant association with CAL formation (P = 0.0436, recessive model). Haplotype analysis did not yield more significant results between polymorphisms of CD40 and susceptibility/disease activity of KD. Conclusions. This study showed for the first time that polymorphisms of CD40 are associated with susceptibility to KD and CAL formation, in the Taiwanese population.
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spelling pubmed-33546842012-05-29 CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population Kuo, Ho-Chang Chao, Mei-Chyn Hsu, Yu-Wen Lin, Ying-Chi Huang, Ying-Hsien Yu, Hong-Ren Hou, Ming-Feng Liang, Chi-Di Yang, Kuender D. Chang, Wei-Chiao Wang, Chih-Lu ScientificWorldJournal Clinical Study Background. Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. Our previous studies showed expression of CD40 ligand on CD4+ T cells correlated to the coronary artery lesion (CAL) and disease progress in KD. Other studies from Japan suggested the role of CD40L in the pathogenesis of CAL, and this might help explain the excessive number of males affected with KD but cannot be reproduced by Taiwanese population. This study was conducted to investigate the CD40 polymorphism in KD and CAL formation. Methods. A total of 950 subjects (381 KD patients and 569 controls) were investigated to identify 2 tagging single-nucleotide polymorphisms (tSNPs) of CD40 (rs4810485 and rs1535045) by using the TaqMan allelic discrimination assay. Results. A significant association was noted with regards to CD40 tSNPs (rs1535045) between controls and KD patients (P = 0.0405, dominant model). In KD patients, polymorphisms of CD40 (rs4810485) showed significant association with CAL formation (P = 0.0436, recessive model). Haplotype analysis did not yield more significant results between polymorphisms of CD40 and susceptibility/disease activity of KD. Conclusions. This study showed for the first time that polymorphisms of CD40 are associated with susceptibility to KD and CAL formation, in the Taiwanese population. The Scientific World Journal 2012-05-02 /pmc/articles/PMC3354684/ /pubmed/22645426 http://dx.doi.org/10.1100/2012/520865 Text en Copyright © 2012 Ho-Chang Kuo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Kuo, Ho-Chang
Chao, Mei-Chyn
Hsu, Yu-Wen
Lin, Ying-Chi
Huang, Ying-Hsien
Yu, Hong-Ren
Hou, Ming-Feng
Liang, Chi-Di
Yang, Kuender D.
Chang, Wei-Chiao
Wang, Chih-Lu
CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population
title CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population
title_full CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population
title_fullStr CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population
title_full_unstemmed CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population
title_short CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population
title_sort cd40 gene polymorphisms associated with susceptibility and coronary artery lesions of kawasaki disease in the taiwanese population
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354684/
https://www.ncbi.nlm.nih.gov/pubmed/22645426
http://dx.doi.org/10.1100/2012/520865
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