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Robust Optimization of Alginate-Carbopol 940 Bead Formulations

Formulation process is a very complex activity which sometimes implicates taking decisions about parameters or variables to obtain the best results in a high variability or uncertainty context. Therefore, robust optimization tools can be very useful for obtaining high quality formulations. This pape...

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Detalles Bibliográficos
Autores principales: López-Cacho, J. M., González-R, Pedro L., Talero, B., Rabasco, A. M., González-Rodríguez, M. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354777/
https://www.ncbi.nlm.nih.gov/pubmed/22645438
http://dx.doi.org/10.1100/2012/605610
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author López-Cacho, J. M.
González-R, Pedro L.
Talero, B.
Rabasco, A. M.
González-Rodríguez, M. L.
author_facet López-Cacho, J. M.
González-R, Pedro L.
Talero, B.
Rabasco, A. M.
González-Rodríguez, M. L.
author_sort López-Cacho, J. M.
collection PubMed
description Formulation process is a very complex activity which sometimes implicates taking decisions about parameters or variables to obtain the best results in a high variability or uncertainty context. Therefore, robust optimization tools can be very useful for obtaining high quality formulations. This paper proposes the optimization of different responses through the robust Taguchi method. Each response was evaluated like a noise variable, allowing the application of Taguchi techniques to obtain a response under the point of view of the signal to noise ratio. A L (18) Taguchi orthogonal array design was employed to investigate the effect of eight independent variables involved in the formulation of alginate-Carbopol beads. Responses evaluated were related to drug release profile from beads (t (50%) and AUC), swelling performance, encapsulation efficiency, shape and size parameters. Confirmation tests to verify the prediction model were carried out and the obtained results were very similar to those predicted in every profile. Results reveal that the robust optimization is a very useful approach that allows greater precision and accuracy to the desired value.
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spelling pubmed-33547772012-05-29 Robust Optimization of Alginate-Carbopol 940 Bead Formulations López-Cacho, J. M. González-R, Pedro L. Talero, B. Rabasco, A. M. González-Rodríguez, M. L. ScientificWorldJournal Research Article Formulation process is a very complex activity which sometimes implicates taking decisions about parameters or variables to obtain the best results in a high variability or uncertainty context. Therefore, robust optimization tools can be very useful for obtaining high quality formulations. This paper proposes the optimization of different responses through the robust Taguchi method. Each response was evaluated like a noise variable, allowing the application of Taguchi techniques to obtain a response under the point of view of the signal to noise ratio. A L (18) Taguchi orthogonal array design was employed to investigate the effect of eight independent variables involved in the formulation of alginate-Carbopol beads. Responses evaluated were related to drug release profile from beads (t (50%) and AUC), swelling performance, encapsulation efficiency, shape and size parameters. Confirmation tests to verify the prediction model were carried out and the obtained results were very similar to those predicted in every profile. Results reveal that the robust optimization is a very useful approach that allows greater precision and accuracy to the desired value. The Scientific World Journal 2012-05-01 /pmc/articles/PMC3354777/ /pubmed/22645438 http://dx.doi.org/10.1100/2012/605610 Text en Copyright © 2012 J. M. López-Cacho et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
López-Cacho, J. M.
González-R, Pedro L.
Talero, B.
Rabasco, A. M.
González-Rodríguez, M. L.
Robust Optimization of Alginate-Carbopol 940 Bead Formulations
title Robust Optimization of Alginate-Carbopol 940 Bead Formulations
title_full Robust Optimization of Alginate-Carbopol 940 Bead Formulations
title_fullStr Robust Optimization of Alginate-Carbopol 940 Bead Formulations
title_full_unstemmed Robust Optimization of Alginate-Carbopol 940 Bead Formulations
title_short Robust Optimization of Alginate-Carbopol 940 Bead Formulations
title_sort robust optimization of alginate-carbopol 940 bead formulations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354777/
https://www.ncbi.nlm.nih.gov/pubmed/22645438
http://dx.doi.org/10.1100/2012/605610
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