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Testosterone and metabolic syndrome: The link
Metabolic syndrome (MetS) or “Syndrome X” which is a constellation of insulin resistance, hyperglycemia, hypertension, low high-density lipoprotein cholesterol (HDL-C), and increased very-low-density lipoprotein (VLDL) and triglyceride (TG) levels. It is one of the main threats for public health in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354945/ https://www.ncbi.nlm.nih.gov/pubmed/22701831 http://dx.doi.org/10.4103/2230-8210.94248 |
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author | Salam, Ranabir Kshetrimayum, Achouba Singh Keisam, Reetu |
author_facet | Salam, Ranabir Kshetrimayum, Achouba Singh Keisam, Reetu |
author_sort | Salam, Ranabir |
collection | PubMed |
description | Metabolic syndrome (MetS) or “Syndrome X” which is a constellation of insulin resistance, hyperglycemia, hypertension, low high-density lipoprotein cholesterol (HDL-C), and increased very-low-density lipoprotein (VLDL) and triglyceride (TG) levels. It is one of the main threats for public health in the 21st century with its associated risk of cardiovascular disease. This condition affects a major chunk of mankind. International Diabetes Federation (IDF) estimated that around 20-25% of the adult population of the world has MetS. Several definitions have been put forward by different expert bodies leading to confusion. To overcome this, joint new statement of many expert group have been issued. Serum testosterone (T) has been shown to be associated with MetS. Several studies have shown a higher prevalence of MetS in subjects with low testosterone. There are also several studies showing a significant difference in serum T between those with MetS and those without. Serum T has also been shown to be associated with components of MetS and testosterone replacement therapy (TRT) improves various metabolic and anthropometric parameters in MetS. Patients with androgen deprivation for treatment of various cancers have also been reported to have higher prevalence of MetS. But the evidence of association is not sufficient evidence for the causation of MetS by low testosterone and long-term studies are needed to confirm whether T deficiency is the cause or is a feature of MetS. |
format | Online Article Text |
id | pubmed-3354945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-33549452012-06-14 Testosterone and metabolic syndrome: The link Salam, Ranabir Kshetrimayum, Achouba Singh Keisam, Reetu Indian J Endocrinol Metab Review Article Metabolic syndrome (MetS) or “Syndrome X” which is a constellation of insulin resistance, hyperglycemia, hypertension, low high-density lipoprotein cholesterol (HDL-C), and increased very-low-density lipoprotein (VLDL) and triglyceride (TG) levels. It is one of the main threats for public health in the 21st century with its associated risk of cardiovascular disease. This condition affects a major chunk of mankind. International Diabetes Federation (IDF) estimated that around 20-25% of the adult population of the world has MetS. Several definitions have been put forward by different expert bodies leading to confusion. To overcome this, joint new statement of many expert group have been issued. Serum testosterone (T) has been shown to be associated with MetS. Several studies have shown a higher prevalence of MetS in subjects with low testosterone. There are also several studies showing a significant difference in serum T between those with MetS and those without. Serum T has also been shown to be associated with components of MetS and testosterone replacement therapy (TRT) improves various metabolic and anthropometric parameters in MetS. Patients with androgen deprivation for treatment of various cancers have also been reported to have higher prevalence of MetS. But the evidence of association is not sufficient evidence for the causation of MetS by low testosterone and long-term studies are needed to confirm whether T deficiency is the cause or is a feature of MetS. Medknow Publications & Media Pvt Ltd 2012-03 /pmc/articles/PMC3354945/ /pubmed/22701831 http://dx.doi.org/10.4103/2230-8210.94248 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Salam, Ranabir Kshetrimayum, Achouba Singh Keisam, Reetu Testosterone and metabolic syndrome: The link |
title | Testosterone and metabolic syndrome: The link |
title_full | Testosterone and metabolic syndrome: The link |
title_fullStr | Testosterone and metabolic syndrome: The link |
title_full_unstemmed | Testosterone and metabolic syndrome: The link |
title_short | Testosterone and metabolic syndrome: The link |
title_sort | testosterone and metabolic syndrome: the link |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354945/ https://www.ncbi.nlm.nih.gov/pubmed/22701831 http://dx.doi.org/10.4103/2230-8210.94248 |
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