Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself

BACKGROUND: Toll-like receptor 4 (TLR4) is activated by bacterial endotoxin, a prototypical pathogen-associated molecular pattern (PAMP). It has been suggested that TLR4 can also be activated by damage-associated molecular pattern (DAMP) proteins such as HSP70. It remains a challenge to provide uneq...

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Detalles Bibliográficos
Autores principales: Luong, Michael, Zhang, Yanyu, Chamberlain, Tim, Zhou, Tianhui, Wright, Jill F, Dower, Ken, Hall, J Perry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355006/
https://www.ncbi.nlm.nih.gov/pubmed/22448747
http://dx.doi.org/10.1186/1476-9255-9-11

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