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Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence?

The brain histaminergic system is one of the diffuse modulatory neurotransmitter systems which regulate neuronal activity in many brain areas. Studies on both rats and mice indicate that histamine H3 receptor antagonists decrease alcohol drinking in several models, like operant alcohol administratio...

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Autores principales: Nuutinen, Saara, Vanhanen, Jenni, Mäki, Tiia, Panula, Pertti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355329/
https://www.ncbi.nlm.nih.gov/pubmed/22629238
http://dx.doi.org/10.3389/fnsys.2012.00036
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author Nuutinen, Saara
Vanhanen, Jenni
Mäki, Tiia
Panula, Pertti
author_facet Nuutinen, Saara
Vanhanen, Jenni
Mäki, Tiia
Panula, Pertti
author_sort Nuutinen, Saara
collection PubMed
description The brain histaminergic system is one of the diffuse modulatory neurotransmitter systems which regulate neuronal activity in many brain areas. Studies on both rats and mice indicate that histamine H3 receptor antagonists decrease alcohol drinking in several models, like operant alcohol administration and drinking in the dark paradigm. Alcohol-induced place preference is also affected by these drugs. Moreover, mice lacking H3R do not drink alcohol like their wild type littermates, and they do not show alcohol-induced place preference. Although the mechanisms of these behaviors are still being investigated, we propose that H3R antagonists are promising candidates for use in human alcoholics, as these drugs are already tested for treatment of other disorders like narcolepsy and sleep disorders.
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spelling pubmed-33553292012-05-24 Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence? Nuutinen, Saara Vanhanen, Jenni Mäki, Tiia Panula, Pertti Front Syst Neurosci Neuroscience The brain histaminergic system is one of the diffuse modulatory neurotransmitter systems which regulate neuronal activity in many brain areas. Studies on both rats and mice indicate that histamine H3 receptor antagonists decrease alcohol drinking in several models, like operant alcohol administration and drinking in the dark paradigm. Alcohol-induced place preference is also affected by these drugs. Moreover, mice lacking H3R do not drink alcohol like their wild type littermates, and they do not show alcohol-induced place preference. Although the mechanisms of these behaviors are still being investigated, we propose that H3R antagonists are promising candidates for use in human alcoholics, as these drugs are already tested for treatment of other disorders like narcolepsy and sleep disorders. Frontiers Research Foundation 2012-05-18 /pmc/articles/PMC3355329/ /pubmed/22629238 http://dx.doi.org/10.3389/fnsys.2012.00036 Text en Copyright © 2012 Nuutinen, Vanhanen, Mäki and Panula. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Neuroscience
Nuutinen, Saara
Vanhanen, Jenni
Mäki, Tiia
Panula, Pertti
Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence?
title Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence?
title_full Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence?
title_fullStr Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence?
title_full_unstemmed Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence?
title_short Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence?
title_sort histamine h3 receptor: a novel therapeutic target in alcohol dependence?
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355329/
https://www.ncbi.nlm.nih.gov/pubmed/22629238
http://dx.doi.org/10.3389/fnsys.2012.00036
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