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Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence?
The brain histaminergic system is one of the diffuse modulatory neurotransmitter systems which regulate neuronal activity in many brain areas. Studies on both rats and mice indicate that histamine H3 receptor antagonists decrease alcohol drinking in several models, like operant alcohol administratio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Research Foundation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355329/ https://www.ncbi.nlm.nih.gov/pubmed/22629238 http://dx.doi.org/10.3389/fnsys.2012.00036 |
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author | Nuutinen, Saara Vanhanen, Jenni Mäki, Tiia Panula, Pertti |
author_facet | Nuutinen, Saara Vanhanen, Jenni Mäki, Tiia Panula, Pertti |
author_sort | Nuutinen, Saara |
collection | PubMed |
description | The brain histaminergic system is one of the diffuse modulatory neurotransmitter systems which regulate neuronal activity in many brain areas. Studies on both rats and mice indicate that histamine H3 receptor antagonists decrease alcohol drinking in several models, like operant alcohol administration and drinking in the dark paradigm. Alcohol-induced place preference is also affected by these drugs. Moreover, mice lacking H3R do not drink alcohol like their wild type littermates, and they do not show alcohol-induced place preference. Although the mechanisms of these behaviors are still being investigated, we propose that H3R antagonists are promising candidates for use in human alcoholics, as these drugs are already tested for treatment of other disorders like narcolepsy and sleep disorders. |
format | Online Article Text |
id | pubmed-3355329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33553292012-05-24 Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence? Nuutinen, Saara Vanhanen, Jenni Mäki, Tiia Panula, Pertti Front Syst Neurosci Neuroscience The brain histaminergic system is one of the diffuse modulatory neurotransmitter systems which regulate neuronal activity in many brain areas. Studies on both rats and mice indicate that histamine H3 receptor antagonists decrease alcohol drinking in several models, like operant alcohol administration and drinking in the dark paradigm. Alcohol-induced place preference is also affected by these drugs. Moreover, mice lacking H3R do not drink alcohol like their wild type littermates, and they do not show alcohol-induced place preference. Although the mechanisms of these behaviors are still being investigated, we propose that H3R antagonists are promising candidates for use in human alcoholics, as these drugs are already tested for treatment of other disorders like narcolepsy and sleep disorders. Frontiers Research Foundation 2012-05-18 /pmc/articles/PMC3355329/ /pubmed/22629238 http://dx.doi.org/10.3389/fnsys.2012.00036 Text en Copyright © 2012 Nuutinen, Vanhanen, Mäki and Panula. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Neuroscience Nuutinen, Saara Vanhanen, Jenni Mäki, Tiia Panula, Pertti Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence? |
title | Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence? |
title_full | Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence? |
title_fullStr | Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence? |
title_full_unstemmed | Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence? |
title_short | Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence? |
title_sort | histamine h3 receptor: a novel therapeutic target in alcohol dependence? |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355329/ https://www.ncbi.nlm.nih.gov/pubmed/22629238 http://dx.doi.org/10.3389/fnsys.2012.00036 |
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