HPV-Associated Head and Neck Cancer: Molecular and Nano-Scale Markers for Prognosis and Therapeutic Stratification

Over the last 10 years, it has become clear that patients with head and neck cancer can be stratified into two distinct subgroups on the basis of the etiology of their disease. Patients with human papillomavirus-related cancers have significantly better survival rates and may necessitate different t...

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Detalles Bibliográficos
Autores principales: Kimple, Adam J., Torres, Alexandra D., Yang, Robert Z., Kimple, Randall J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355463/
https://www.ncbi.nlm.nih.gov/pubmed/22666080
http://dx.doi.org/10.3390/s120405159
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author Kimple, Adam J.
Torres, Alexandra D.
Yang, Robert Z.
Kimple, Randall J.
author_facet Kimple, Adam J.
Torres, Alexandra D.
Yang, Robert Z.
Kimple, Randall J.
author_sort Kimple, Adam J.
collection PubMed
description Over the last 10 years, it has become clear that patients with head and neck cancer can be stratified into two distinct subgroups on the basis of the etiology of their disease. Patients with human papillomavirus-related cancers have significantly better survival rates and may necessitate different therapeutic approaches than those with tobacco and/or alcohol related cancers. This review discusses the various biomarkers currently in use for identification of patients with HPV-positive cancers with a focus on the advantages and limitations of molecular and nano-scale markers.
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spelling pubmed-33554632012-06-04 HPV-Associated Head and Neck Cancer: Molecular and Nano-Scale Markers for Prognosis and Therapeutic Stratification Kimple, Adam J. Torres, Alexandra D. Yang, Robert Z. Kimple, Randall J. Sensors (Basel) Review Over the last 10 years, it has become clear that patients with head and neck cancer can be stratified into two distinct subgroups on the basis of the etiology of their disease. Patients with human papillomavirus-related cancers have significantly better survival rates and may necessitate different therapeutic approaches than those with tobacco and/or alcohol related cancers. This review discusses the various biomarkers currently in use for identification of patients with HPV-positive cancers with a focus on the advantages and limitations of molecular and nano-scale markers. Molecular Diversity Preservation International (MDPI) 2012-04-20 /pmc/articles/PMC3355463/ /pubmed/22666080 http://dx.doi.org/10.3390/s120405159 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Kimple, Adam J.
Torres, Alexandra D.
Yang, Robert Z.
Kimple, Randall J.
HPV-Associated Head and Neck Cancer: Molecular and Nano-Scale Markers for Prognosis and Therapeutic Stratification
title HPV-Associated Head and Neck Cancer: Molecular and Nano-Scale Markers for Prognosis and Therapeutic Stratification
title_full HPV-Associated Head and Neck Cancer: Molecular and Nano-Scale Markers for Prognosis and Therapeutic Stratification
title_fullStr HPV-Associated Head and Neck Cancer: Molecular and Nano-Scale Markers for Prognosis and Therapeutic Stratification
title_full_unstemmed HPV-Associated Head and Neck Cancer: Molecular and Nano-Scale Markers for Prognosis and Therapeutic Stratification
title_short HPV-Associated Head and Neck Cancer: Molecular and Nano-Scale Markers for Prognosis and Therapeutic Stratification
title_sort hpv-associated head and neck cancer: molecular and nano-scale markers for prognosis and therapeutic stratification
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355463/
https://www.ncbi.nlm.nih.gov/pubmed/22666080
http://dx.doi.org/10.3390/s120405159
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