Cargando…

The Nef-Infectivity Enigma: Mechanisms of Enhanced Lentiviral Infection

The Nef protein is an essential factor for lentiviral pathogenesis in humans and other simians. Despite a multitude of functions attributed to this protein, the exact role of Nef in disease progression remains unclear. One of its most intriguing functions is the ability of Nef to enhance the infecti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vermeire, Jolien, Vanbillemont, Griet, Witkowski, Wojciech, Verhasselt, Bruno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355465/ https://www.ncbi.nlm.nih.gov/pubmed/22103831 http://dx.doi.org/10.2174/157016211798842099

Ejemplares similares

Vpx-Independent Lentiviral Transduction and shRNA-Mediated Protein Knock-Down in Monocyte-Derived Dendritic Cells
por: Witkowski, Wojciech, et al.
Publicado: (2015)

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms
por: Van Nuffel, Anouk, et al.
Publicado: (2013)

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function
por: Meuwissen, Pieter J, et al.
Publicado: (2012)

Link between Primate Lentiviral Coreceptor Usage and Nef Function
por: Schmökel, Jan, et al.
Publicado: (2013)

Evaluation of pathways and new host proteins involved in CD4 down-modulation during HIV-1 infection
por: Landi, Alessia, et al.
Publicado: (2011)

New host factors and pathways involved in CD4 downregulation in HIV-1 infected cells
por: Landi, Alessia, et al.
Publicado: (2013)

HIV-1 infection induces a type I IFN response in primary CD4(+) T cells
por: Vermeire, Jolien, et al.
Publicado: (2013)

Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex
por: Imle, Andrea, et al.
Publicado: (2015)

One Protein to Rule them All: Modulation of Cell Surface Receptors and Molecules by HIV Nef
por: Landi, Alessia, et al.
Publicado: (2011)

The enhancement of HIV-1 infectivity by Nef depends on dynamin 2
por: Pizzato, Massimo, et al.
Publicado: (2006)

Nef interferes with development of thymic T cell precursors: differential mechanisms in HIV and SIV
por: Meuwissen, PJ, et al.
Publicado: (2011)

Evolutionary plasticity of SH3 domain binding by Nef proteins of the HIV-1/SIVcpz lentiviral lineage
por: Zhao, Zhe, et al.
Publicado: (2021)

The activity of Nef on HIV-1 infectivity
por: Basmaciogullari, Stéphane, et al.
Publicado: (2014)

Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection
por: Höhne, Kristin, et al.
Publicado: (2016)

Lentiviral Nef suppresses iron uptake in a strain specific manner through inhibition of Transferrin endocytosis
por: Koppensteiner, Herwig, et al.
Publicado: (2014)

Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation
por: Landi, Alessia, et al.
Publicado: (2014)

Use of RNA interference to discover pathways involved in HIV infection and replication: cell lines tell many stories, primary cells might tell the truth
por: lannucci, Veronica, et al.
Publicado: (2011)

Clearly different mechanisms of enhancement of short-lived Nef-mediated viral infectivity between SIV and HIV-1
por: Harada, Keisuke, et al.
Publicado: (2014)

Nef enhances HIV-1 replication and infectivity independently of SERINC5 in CEM T cells
por: Ramirez, Peter W., et al.
Publicado: (2023)

Differential Regulation of NF-κB-Mediated Proviral and Antiviral Host Gene Expression by Primate Lentiviral Nef and Vpu Proteins
por: Sauter, Daniel, et al.
Publicado: (2015)

Understanding the nature of the Nef requirement for HIV-1 infectivity
por: Rosa, Annachiara, et al.
Publicado: (2013)

Hepcidin and the iron enigma in HCV infection
por: Georgopoulou, Urania, et al.
Publicado: (2014)

Immunogenetics of Small Ruminant Lentiviral Infections
por: Stonos, Nancy, et al.
Publicado: (2014)

Efficient, Vpx independent shRNA transduction of monocyte derived dendritic cells as a tool for studying HIV transmission to primary T-cells
por: Witkowski, Wojciech, et al.
Publicado: (2013)

Nef variants from non-pathogenic lentiviral strains inhibit iron uptake through an AP2-dependent inhibition of transferrin endocytosis
por: Koppensteiner, Herwig, et al.
Publicado: (2013)

The Identification of a Small Molecule Compound That Reduces HIV-1 Nef-Mediated Viral Infectivity Enhancement
por: Chutiwitoonchai, Nopporn, et al.
Publicado: (2011)

Replication competent virus as an important source of bias in HIV latency models utilizing single round viral constructs
por: Bonczkowski, Pawel, et al.
Publicado: (2014)

Characterization of Nef expression in different brain regions of SIV-infected macaques
por: Yarandi, Shadan S., et al.
Publicado: (2020)

HYPERCOAGULABLE STATE: AN ENIGMA IN COVID-19 INFECTION
por: MILI, SAIMA, et al.
Publicado: (2021)

Quantification of Reverse Transcriptase Activity by Real-Time PCR as a Fast and Accurate Method for Titration of HIV, Lenti- and Retroviral Vectors
por: Vermeire, Jolien, et al.
Publicado: (2012)

SARS CoV-2 Nucleoprotein Enhances the Infectivity of Lentiviral Spike Particles
por: Mishra, Tarun, et al.
Publicado: (2021)

HIV-1 Infection of T Lymphocytes and Macrophages Affects Their Migration via Nef
por: Vérollet, Christel, et al.
Publicado: (2015)

Dendritic cell nediated inhibition of lentiviral infection
por: Drake, A, et al.
Publicado: (2012)

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef
por: Usami, Yoshiko, et al.
Publicado: (2015)

HIV-1 Nef targets calnexin: a novel mechanism behind Nef effects on host cell and viral proteins
por: Jennelle, Lucas, et al.
Publicado: (2013)

HIV-1 Nef Protein Structures Associated with Brain Infection and Dementia Pathogenesis
por: Lamers, Susanna L., et al.
Publicado: (2011)

Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes
por: Painter, Mark M., et al.
Publicado: (2020)

Enigmas of primary immunodeficiency and mycobacterial infection in our territory
por: Sherkat, Roya
Publicado: (2014)

The Enigma of Lymphocyte Apoptosis in the Response to Influenza Virus Infection
por: Roberts, Norbert J.
Publicado: (2023)

Recent Advances in Lentiviral Vaccines for HIV-1 Infection
por: Norton, Thomas D., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_1ig4eha393ifbgjj2jl31l3u2p