Multiple Transport Pathways for Mediating Intracellular pH Homeostasis: The Contribution of H(+)/ion Exchangers

Intracellular pH homeostasis is an essential process in all plant cells. The transport of H(+) into intracellular compartments is critical for providing pH regulation. The maintenance of correct luminal pH in the vacuole and in compartments of the secretory/endocytic pathway is important for a variety of cellular functions including protein modification, sorting, and trafficking. It is becoming increasingly evident that coordination between primary H(+) pumps, most notably the V-ATPase, and secondary ion/H(+) exchangers allows this endomembrane pH maintenance to occur. This article describes some of the recent insights from the studies of plant cation/H(+) exchangers and anion/H(+) exchangers that demonstrate the fundamental roles of these transporters in pH homeostasis within intracellular compartments.