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Surgical Strategies in Childhood Craniopharyngioma

Craniopharyngiomas are biologically benign lesions (WHO Grade 1) of the sellar and suprasellar region, associated with a serious morbidity. About 50% of these tumors become clinically apparent during childhood. Clinical symptoms include headaches, chiasm syndrome, hydrocephalus, pituitary insufficie...

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Autores principales: Flitsch, Jörg, Müller, Hermann Lothar, Burkhardt, Till
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355821/
https://www.ncbi.nlm.nih.gov/pubmed/22645514
http://dx.doi.org/10.3389/fendo.2011.00096
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author Flitsch, Jörg
Müller, Hermann Lothar
Burkhardt, Till
author_facet Flitsch, Jörg
Müller, Hermann Lothar
Burkhardt, Till
author_sort Flitsch, Jörg
collection PubMed
description Craniopharyngiomas are biologically benign lesions (WHO Grade 1) of the sellar and suprasellar region, associated with a serious morbidity. About 50% of these tumors become clinically apparent during childhood. Clinical symptoms include headaches, chiasm syndrome, hydrocephalus, pituitary insufficiencies, and obesity. Growth arrest is a typical symptom in children. The treatment of craniopharyngiomas includes surgery as well as radiotherapy. The goal of surgery varies according to the tumor location and extension and may range from complete resection to biopsy. Surgical complications are well known and cause constant evaluation of surgical strategies. Diencephalic obesity is related to surgical manipulation of hypothalamic tissue. Therefore, a classification system for craniopharyngiomas based on preoperative MRI is suggested by the authors. Recurrences are frequent in craniopharyngiomas, even after complete or gross-total resection. Radiotherapy is therefore recommended to patients with incomplete resections. However, the ideal time for radiotherapy after surgery is under discussion. The treatment of craniopharyngiomas requires an interdisciplinary and multimodal approach. Each patient should receive an individually tailored treatment. Surgically, different approaches as well as different degrees of resection can be considered, depending on tumor location and tumor extension.
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spelling pubmed-33558212012-05-29 Surgical Strategies in Childhood Craniopharyngioma Flitsch, Jörg Müller, Hermann Lothar Burkhardt, Till Front Endocrinol (Lausanne) Endocrinology Craniopharyngiomas are biologically benign lesions (WHO Grade 1) of the sellar and suprasellar region, associated with a serious morbidity. About 50% of these tumors become clinically apparent during childhood. Clinical symptoms include headaches, chiasm syndrome, hydrocephalus, pituitary insufficiencies, and obesity. Growth arrest is a typical symptom in children. The treatment of craniopharyngiomas includes surgery as well as radiotherapy. The goal of surgery varies according to the tumor location and extension and may range from complete resection to biopsy. Surgical complications are well known and cause constant evaluation of surgical strategies. Diencephalic obesity is related to surgical manipulation of hypothalamic tissue. Therefore, a classification system for craniopharyngiomas based on preoperative MRI is suggested by the authors. Recurrences are frequent in craniopharyngiomas, even after complete or gross-total resection. Radiotherapy is therefore recommended to patients with incomplete resections. However, the ideal time for radiotherapy after surgery is under discussion. The treatment of craniopharyngiomas requires an interdisciplinary and multimodal approach. Each patient should receive an individually tailored treatment. Surgically, different approaches as well as different degrees of resection can be considered, depending on tumor location and tumor extension. Frontiers Research Foundation 2011-12-23 /pmc/articles/PMC3355821/ /pubmed/22645514 http://dx.doi.org/10.3389/fendo.2011.00096 Text en Copyright © 2011 Flitsch, Müller and Burkhardt. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Endocrinology
Flitsch, Jörg
Müller, Hermann Lothar
Burkhardt, Till
Surgical Strategies in Childhood Craniopharyngioma
title Surgical Strategies in Childhood Craniopharyngioma
title_full Surgical Strategies in Childhood Craniopharyngioma
title_fullStr Surgical Strategies in Childhood Craniopharyngioma
title_full_unstemmed Surgical Strategies in Childhood Craniopharyngioma
title_short Surgical Strategies in Childhood Craniopharyngioma
title_sort surgical strategies in childhood craniopharyngioma
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355821/
https://www.ncbi.nlm.nih.gov/pubmed/22645514
http://dx.doi.org/10.3389/fendo.2011.00096
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