Integration of Principles of Systems Biology and Radiation Biology: Toward Development of in silico Models to Optimize IUdR-Mediated Radiosensitization of DNA Mismatch Repair Deficient (Damage Tolerant) Human Cancers

Over the last 7 years, we have focused our experimental and computational research efforts on improving our understanding of the biochemical, molecular, and cellular processing of iododeoxyuridine (IUdR) and ionizing radiation (IR) induced DNA base damage by DNA mismatch repair (MMR). These coordina...

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Detalles Bibliográficos
Autores principales: Kinsella, Timothy J., Gurkan-Cavusoglu, Evren, Du, Weinan, Loparo, Kenneth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355906/
https://www.ncbi.nlm.nih.gov/pubmed/22649757
http://dx.doi.org/10.3389/fonc.2011.00020

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