Timing is Everything: PTTH Mediated DHR4 Nucleocytoplasmic Trafficking Sets the Tempo of Drosophila Steroid Production

During development, multicellular organisms must become sexually mature in order to reproduce. The developmental timing of this transition is controlled by pulses of steroid hormones, but how these pulses are generated have remained unclear? A recent paper shows that in Drosophila larvae, nucleocyto...

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Detalles Bibliográficos
Autores principales: Rewitz, Kim F., O’Connor, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355928/
https://www.ncbi.nlm.nih.gov/pubmed/22649397
http://dx.doi.org/10.3389/fendo.2011.00108
Descripción
Sumario:During development, multicellular organisms must become sexually mature in order to reproduce. The developmental timing of this transition is controlled by pulses of steroid hormones, but how these pulses are generated have remained unclear? A recent paper shows that in Drosophila larvae, nucleocytoplasmic trafficking of DHR4, a nuclear receptor, in response to prothoracicotropic hormone signaling, is critical for producing the correct temporal pulses of steroid hormones that coordinate the juvenile–adult transition.

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