Timing is Everything: PTTH Mediated DHR4 Nucleocytoplasmic Trafficking Sets the Tempo of Drosophila Steroid Production

During development, multicellular organisms must become sexually mature in order to reproduce. The developmental timing of this transition is controlled by pulses of steroid hormones, but how these pulses are generated have remained unclear? A recent paper shows that in Drosophila larvae, nucleocyto...

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Detalles Bibliográficos
Autores principales: Rewitz, Kim F., O’Connor, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355928/
https://www.ncbi.nlm.nih.gov/pubmed/22649397
http://dx.doi.org/10.3389/fendo.2011.00108
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author Rewitz, Kim F.
O’Connor, Michael B.
author_facet Rewitz, Kim F.
O’Connor, Michael B.
author_sort Rewitz, Kim F.
collection PubMed
description During development, multicellular organisms must become sexually mature in order to reproduce. The developmental timing of this transition is controlled by pulses of steroid hormones, but how these pulses are generated have remained unclear? A recent paper shows that in Drosophila larvae, nucleocytoplasmic trafficking of DHR4, a nuclear receptor, in response to prothoracicotropic hormone signaling, is critical for producing the correct temporal pulses of steroid hormones that coordinate the juvenile–adult transition.
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spelling pubmed-33559282012-05-30 Timing is Everything: PTTH Mediated DHR4 Nucleocytoplasmic Trafficking Sets the Tempo of Drosophila Steroid Production Rewitz, Kim F. O’Connor, Michael B. Front Endocrinol (Lausanne) Endocrinology During development, multicellular organisms must become sexually mature in order to reproduce. The developmental timing of this transition is controlled by pulses of steroid hormones, but how these pulses are generated have remained unclear? A recent paper shows that in Drosophila larvae, nucleocytoplasmic trafficking of DHR4, a nuclear receptor, in response to prothoracicotropic hormone signaling, is critical for producing the correct temporal pulses of steroid hormones that coordinate the juvenile–adult transition. Frontiers Research Foundation 2011-12-27 /pmc/articles/PMC3355928/ /pubmed/22649397 http://dx.doi.org/10.3389/fendo.2011.00108 Text en Copyright © 2011 Rewitz and O’Connor. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Endocrinology
Rewitz, Kim F.
O’Connor, Michael B.
Timing is Everything: PTTH Mediated DHR4 Nucleocytoplasmic Trafficking Sets the Tempo of Drosophila Steroid Production
title Timing is Everything: PTTH Mediated DHR4 Nucleocytoplasmic Trafficking Sets the Tempo of Drosophila Steroid Production
title_full Timing is Everything: PTTH Mediated DHR4 Nucleocytoplasmic Trafficking Sets the Tempo of Drosophila Steroid Production
title_fullStr Timing is Everything: PTTH Mediated DHR4 Nucleocytoplasmic Trafficking Sets the Tempo of Drosophila Steroid Production
title_full_unstemmed Timing is Everything: PTTH Mediated DHR4 Nucleocytoplasmic Trafficking Sets the Tempo of Drosophila Steroid Production
title_short Timing is Everything: PTTH Mediated DHR4 Nucleocytoplasmic Trafficking Sets the Tempo of Drosophila Steroid Production
title_sort timing is everything: ptth mediated dhr4 nucleocytoplasmic trafficking sets the tempo of drosophila steroid production
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355928/
https://www.ncbi.nlm.nih.gov/pubmed/22649397
http://dx.doi.org/10.3389/fendo.2011.00108
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