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Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging

The roles of estrogens have been best studied in the breast, breast cancers, and in the female reproductive tract. However, estrogens have important functions in almost every tissue in the body. Recent clinical trials such as the Women’s Health Initiative have highlighted both the importance of estr...

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Detalles Bibliográficos
Autores principales: Wend, Korinna, Wend, Peter, Krum, Susan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356020/
https://www.ncbi.nlm.nih.gov/pubmed/22654856
http://dx.doi.org/10.3389/fendo.2012.00019
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author Wend, Korinna
Wend, Peter
Krum, Susan A.
author_facet Wend, Korinna
Wend, Peter
Krum, Susan A.
author_sort Wend, Korinna
collection PubMed
description The roles of estrogens have been best studied in the breast, breast cancers, and in the female reproductive tract. However, estrogens have important functions in almost every tissue in the body. Recent clinical trials such as the Women’s Health Initiative have highlighted both the importance of estrogens and how little we know about the molecular mechanism of estrogens in these other tissues. In this review, we illustrate the diverse functions of estrogens in the bone, adipose tissue, skin, hair, brain, skeletal muscle and cardiovascular system, and how the loss of estrogens during aging affects these tissues. Early transcriptional targets of estrogen are reviewed in each tissue. We also describe the tissue-specific effects of selective estrogen receptor modulators (SERMs) used for the treatment of breast cancers and postmenopausal symptoms.
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spelling pubmed-33560202012-05-31 Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging Wend, Korinna Wend, Peter Krum, Susan A. Front Endocrinol (Lausanne) Endocrinology The roles of estrogens have been best studied in the breast, breast cancers, and in the female reproductive tract. However, estrogens have important functions in almost every tissue in the body. Recent clinical trials such as the Women’s Health Initiative have highlighted both the importance of estrogens and how little we know about the molecular mechanism of estrogens in these other tissues. In this review, we illustrate the diverse functions of estrogens in the bone, adipose tissue, skin, hair, brain, skeletal muscle and cardiovascular system, and how the loss of estrogens during aging affects these tissues. Early transcriptional targets of estrogen are reviewed in each tissue. We also describe the tissue-specific effects of selective estrogen receptor modulators (SERMs) used for the treatment of breast cancers and postmenopausal symptoms. Frontiers Research Foundation 2012-02-08 /pmc/articles/PMC3356020/ /pubmed/22654856 http://dx.doi.org/10.3389/fendo.2012.00019 Text en Copyright © 2012 Wend, Wend and Krum. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Endocrinology
Wend, Korinna
Wend, Peter
Krum, Susan A.
Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging
title Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging
title_full Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging
title_fullStr Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging
title_full_unstemmed Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging
title_short Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging
title_sort tissue-specific effects of loss of estrogen during menopause and aging
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356020/
https://www.ncbi.nlm.nih.gov/pubmed/22654856
http://dx.doi.org/10.3389/fendo.2012.00019
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