An Optically Pure Apogossypolone Derivative as Potent Pan-Active Inhibitor of Anti-Apoptotic Bcl-2 Family Proteins

Our focus in the past several years has been on the identification of novel and effective pan-Bcl-2 antagonists. We have recently reported a series of Apogossypolone (ApoG2) derivatives, resulting in the chiral compound (±) BI97D6. We report here the synthesis and evaluation on its optically pure (−...

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Detalles Bibliográficos
Autores principales: Wei, Jun, Stebbins, John L., Kitada, Shinichi, Dash, Rupesh, Zhai, Dayong, Placzek, William J., Wu, Bainan, Rega, Michele F., Zhang, Ziming, Barile, Elisa, Yang, Li, Dahl, Russell, Fisher, Paul B., Reed, John C., Pellecchia, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356046/
https://www.ncbi.nlm.nih.gov/pubmed/22655238
http://dx.doi.org/10.3389/fonc.2011.00028

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