Deep Sequence Analysis of Non-Small Cell Lung Cancer: Integrated Analysis of Gene Expression, Alternative Splicing, and Single Nucleotide Variations in Lung Adenocarcinomas with and without Oncogenic KRAS Mutations

KRAS mutations are highly prevalent in non-small cell lung cancer (NSCLC), and tumors harboring these mutations tend to be aggressive and resistant to chemotherapy. We used next-generation sequencing technology to identify pathways that are specifically altered in lung tumors harboring a KRAS mutati...

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Detalles Bibliográficos
Autores principales: Kalari, Krishna R., Rossell, David, Necela, Brian M., Asmann, Yan W., Nair, Asha, Baheti, Saurabh, Kachergus, Jennifer M., Younkin, Curtis S., Baker, Tiffany, Carr, Jennifer M., Tang, Xiaojia, Walsh, Michael P., Chai, High-Seng, Sun, Zhifu, Hart, Steven N., Leontovich, Alexey A., Hossain, Asif, Kocher, Jean-Pierre, Perez, Edith A., Reisman, David N., Fields, Alan P., Thompson, E. Aubrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356053/
https://www.ncbi.nlm.nih.gov/pubmed/22655260
http://dx.doi.org/10.3389/fonc.2012.00012

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