Cargando…

Enhancing cellular uptake of activable cell-penetrating peptide–doxorubicin conjugate by enzymatic cleavage

The use of activable cell-penetrating peptides (ACPPs) as molecular imaging probes is a promising new approach for the visualization of enzymes. The cell-penetrating function of a polycationic cell-penetrating peptide (CPP) is efficiently blocked by intramolecular electrostatic interactions with a p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Nian-Qiu, Gao, Wei, Xiang, Bai, Qi, Xian-Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356196/ https://www.ncbi.nlm.nih.gov/pubmed/22619516 http://dx.doi.org/10.2147/IJN.S30104

Ejemplares similares

Contrasting roles for actin in the cellular uptake of cell penetrating peptide conjugates
por: He, L., et al.
Publicado: (2018)

Deepened cellular/subcellular interface penetration and enhanced antitumor efficacy of cyclic peptidic ligand-decorated accelerating active targeted nanomedicines
por: Shi, Nian-Qiu, et al.
Publicado: (2018)

Enhanced cellular uptake of lactosomes using cell-penetrating peptides
por: Akahoshi, Akiya, et al.
Publicado: (2016)

Cellular uptake and anti-tumor activity of gemcitabine conjugated with new amphiphilic cell penetrating peptides
por: Zakeri-Milani, Parvin, et al.
Publicado: (2017)

Mechanisms of Cellular Uptake of Cell-Penetrating Peptides
por: Madani, Fatemeh, et al.
Publicado: (2011)

Synthesis, Characterization, Cellular Uptake, and In Vitro Anticancer Activity of Fullerenol-Doxorubicin Conjugates
por: Xu, Beihua, et al.
Publicado: (2021)

Decoration of pH-sensitive copolymer micelles with tumor-specific peptide for enhanced cellular uptake of doxorubicin
por: Chen, Qing, et al.
Publicado: (2016)

Dimerization of a cell-penetrating peptide leads to enhanced cellular uptake and drug delivery
por: Hoyer, Jan, et al.
Publicado: (2012)

Conjugation of Cell-Penetrating Peptides to Antimicrobial Peptides Enhances Antibacterial Activity
por: Lee, Hyunhee, et al.
Publicado: (2019)

Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems
por: Trabulo, Sara, et al.
Publicado: (2010)

The Product of Matrix Metalloproteinase Cleavage of Doxorubicin Conjugate for Anticancer Drug Delivery: Calorimetric, Spectroscopic, and Molecular Dynamics Studies on Peptide–Doxorubicin Binding to DNA
por: Butowska, Kamila, et al.
Publicado: (2020)

Magnetically Driven Muco-Inert Janus Nanovehicles for Enhanced Mucus Penetration and Cellular Uptake
por: Hao, Yue, et al.
Publicado: (2022)

Enhanced Cellular Uptake and Pharmacokinetic Characteristics of Doxorubicin-Valine Amide Prodrug
por: Park, Yohan, et al.
Publicado: (2016)

Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer
por: Salaam, Amanee D, et al.
Publicado: (2014)

Dual Peptide Conjugation Strategy for Improved Cellular Uptake and Mitochondria Targeting
por: Lin, Ran, et al.
Publicado: (2014)

The influence of degree of labelling upon cellular internalisation of antibody-cell penetrating peptide conjugates
por: Pringle, Toni A., et al.
Publicado: (2022)

Synthesis, cellular uptake and HIV-1 Tat-dependent trans-activation inhibition activity of oligonucleotide analogues disulphide-conjugated to cell-penetrating peptides
por: Turner, John J., et al.
Publicado: (2005)

Cell Penetrating Peptide Conjugated Chitosan for Enhanced Delivery of Nucleic Acid
por: Layek, Buddhadev, et al.
Publicado: (2015)

Influence of the Dabcyl group on the cellular uptake of cationic peptides: short oligoarginines as efficient cell-penetrating peptides
por: Szabó, Ildikó, et al.
Publicado: (2021)

Cell-penetrating peptide conjugates to enhance the antitumor effect of paclitaxel on drug-resistant lung cancer
por: Duan, Ziqing, et al.
Publicado: (2017)

Enhanced Cellular Uptake of Albumin-Based Lyophilisomes when Functionalized with Cell-Penetrating Peptide TAT in HeLa Cells
por: van Bracht, Etienne, et al.
Publicado: (2014)

Tumor-penetrating Peptide Conjugated and Doxorubicin Loaded T(1)-T(2) Dual Mode MRI Contrast Agents Nanoparticles for Tumor Theranostics
por: Gao, Lipeng, et al.
Publicado: (2018)

Interdependence of charge and secondary structure on cellular uptake of cell penetrating peptide functionalized silica nanoparticles
por: Gessner, Isabel, et al.
Publicado: (2019)

Correction: Enhanced Cellular Uptake of Albumin-Based Lyophilisomes when Functionalized with Cell-Penetrating Peptide TAT in HeLa Cells
Publicado: (2015)

Antimicrobial and Cell-Penetrating Peptides: Understanding Penetration for the Design of Novel Conjugate Antibiotics
por: Hadjicharalambous, Andreas, et al.
Publicado: (2022)

Evaluation of Floxuridine Oligonucleotide Conjugates Carrying Potential Enhancers of Cellular Uptake
por: Aviñó, Anna, et al.
Publicado: (2021)

Morphological transformation enhances Tumor Retention by Regulating the Self-assembly of Doxorubicin-peptide Conjugates
por: Xu, Liu, et al.
Publicado: (2020)

Cooperative Cellular Uptake and Activity of Octaarginine Antisense Peptide Nucleic Acid (PNA) Conjugates
por: Ghavami, Mahdi, et al.
Publicado: (2019)

Photodynamic therapy by conjugation of cell-penetrating peptide with fluorochrome
por: Park, Chul-Kyu, et al.
Publicado: (2017)

Cell penetrating peptide conjugates of steric block oligonucleotides()
por: Lebleu, Bernard, et al.
Publicado: (2008)

In Vitro and In Vivo Cell Uptake of a Cell-Penetrating Peptide Conjugated with Fluorescent Dyes Having Different Chemical Properties
por: Takakura, Hideo, et al.
Publicado: (2021)

Stepwise pH-responsive nanoparticles for enhanced cellular uptake and on-demand intracellular release of doxorubicin
por: Chen, Wei-liang, et al.
Publicado: (2017)

AntimiR-155 Cyclic Peptide–PNA Conjugate: Synthesis, Cellular Uptake, and Biological Activity
por: Soudah, Terese, et al.
Publicado: (2019)

Effects of the properties of short peptides conjugated with cell-penetrating peptides on their internalization into cells
por: Matsumoto, Ryo, et al.
Publicado: (2015)

Recent developments in the cleavage, functionalization, and conjugation of proteins and peptides at tyrosine residues
por: Zhang, Shengping, et al.
Publicado: (2023)

Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides
por: Lättig-Tünnemann, Gisela, et al.
Publicado: (2011)

Neuropilin-1 and heparan sulfate proteoglycans cooperate in cellular uptake of nanoparticles functionalized by cationic cell-penetrating peptides
por: Pang, Hong-Bo, et al.
Publicado: (2015)

Molecular Dynamics Simulations of Drug-Conjugated Cell-Penetrating Peptides
por: Ivánczi, Márton, et al.
Publicado: (2023)

Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood–Brain Barrier Adherence, Uptake, and Permeation
por: Kristensen, Mie, et al.
Publicado: (2020)

Cell-penetrating peptide conjugates of gambogic acid enhance the antitumor effect on human bladder cancer EJ cells through ROS-mediated apoptosis
por: Lyu, Lei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_n5srd1jb1af3v07o7umnbs9s46