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IL-15 Participates in the Respiratory Innate Immune Response to Influenza Virus Infection

Following influenza infection, natural killer (NK) cells function as interim effectors by suppressing viral replication until CD8 T cells are activated, proliferate, and are mobilized within the respiratory tract. Thus, NK cells are an important first line of defense against influenza virus. Here, i...

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Detalles Bibliográficos
Autores principales: Verbist, Katherine C., Rose, David L., Cole, Charles J., Field, Mary B., Klonowski, Kimberly D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356330/
https://www.ncbi.nlm.nih.gov/pubmed/22624047
http://dx.doi.org/10.1371/journal.pone.0037539
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author Verbist, Katherine C.
Rose, David L.
Cole, Charles J.
Field, Mary B.
Klonowski, Kimberly D.
author_facet Verbist, Katherine C.
Rose, David L.
Cole, Charles J.
Field, Mary B.
Klonowski, Kimberly D.
author_sort Verbist, Katherine C.
collection PubMed
description Following influenza infection, natural killer (NK) cells function as interim effectors by suppressing viral replication until CD8 T cells are activated, proliferate, and are mobilized within the respiratory tract. Thus, NK cells are an important first line of defense against influenza virus. Here, in a murine model of influenza, we show that virally-induced IL-15 facilitates the trafficking of NK cells into the lung airways. Blocking IL-15 delays NK cell entry to the site of infection and results in a disregulated control of early viral replication. By the same principle, viral control by NK cells can be therapeutically enhanced via intranasal administration of exogenous IL-15 in the early days post influenza infection. In addition to controlling early viral replication, this IL-15-induced mobilization of NK cells to the lung airways has important downstream consequences on adaptive responses. Primarily, depletion of responding NK1.1+ NK cells is associated with reduced immigration of influenza-specific CD8 T cells to the site of infection. Together this work suggests that local deposits of IL-15 in the lung airways regulate the coordinated innate and adaptive immune responses to influenza infection and may represent an important point of immune intervention.
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spelling pubmed-33563302012-05-23 IL-15 Participates in the Respiratory Innate Immune Response to Influenza Virus Infection Verbist, Katherine C. Rose, David L. Cole, Charles J. Field, Mary B. Klonowski, Kimberly D. PLoS One Research Article Following influenza infection, natural killer (NK) cells function as interim effectors by suppressing viral replication until CD8 T cells are activated, proliferate, and are mobilized within the respiratory tract. Thus, NK cells are an important first line of defense against influenza virus. Here, in a murine model of influenza, we show that virally-induced IL-15 facilitates the trafficking of NK cells into the lung airways. Blocking IL-15 delays NK cell entry to the site of infection and results in a disregulated control of early viral replication. By the same principle, viral control by NK cells can be therapeutically enhanced via intranasal administration of exogenous IL-15 in the early days post influenza infection. In addition to controlling early viral replication, this IL-15-induced mobilization of NK cells to the lung airways has important downstream consequences on adaptive responses. Primarily, depletion of responding NK1.1+ NK cells is associated with reduced immigration of influenza-specific CD8 T cells to the site of infection. Together this work suggests that local deposits of IL-15 in the lung airways regulate the coordinated innate and adaptive immune responses to influenza infection and may represent an important point of immune intervention. Public Library of Science 2012-05-18 /pmc/articles/PMC3356330/ /pubmed/22624047 http://dx.doi.org/10.1371/journal.pone.0037539 Text en Verbist et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Verbist, Katherine C.
Rose, David L.
Cole, Charles J.
Field, Mary B.
Klonowski, Kimberly D.
IL-15 Participates in the Respiratory Innate Immune Response to Influenza Virus Infection
title IL-15 Participates in the Respiratory Innate Immune Response to Influenza Virus Infection
title_full IL-15 Participates in the Respiratory Innate Immune Response to Influenza Virus Infection
title_fullStr IL-15 Participates in the Respiratory Innate Immune Response to Influenza Virus Infection
title_full_unstemmed IL-15 Participates in the Respiratory Innate Immune Response to Influenza Virus Infection
title_short IL-15 Participates in the Respiratory Innate Immune Response to Influenza Virus Infection
title_sort il-15 participates in the respiratory innate immune response to influenza virus infection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356330/
https://www.ncbi.nlm.nih.gov/pubmed/22624047
http://dx.doi.org/10.1371/journal.pone.0037539
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