Methylation-Mediated Molecular Dysregulation in Clinical Oral Malignancy

Herein we provide a concise review of the state of methylation research as it pertains to clinical oral cancerous and precancerous tissues. We provide context for ongoing research efforts in this field and describe technologies that are presently being applied to analyze clinical specimens. We also...

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Detalles Bibliográficos
Autores principales: Towle, Rebecca, Garnis, Cathie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356707/
https://www.ncbi.nlm.nih.gov/pubmed/22645611
http://dx.doi.org/10.1155/2012/170172
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author Towle, Rebecca
Garnis, Cathie
author_facet Towle, Rebecca
Garnis, Cathie
author_sort Towle, Rebecca
collection PubMed
description Herein we provide a concise review of the state of methylation research as it pertains to clinical oral cancerous and precancerous tissues. We provide context for ongoing research efforts in this field and describe technologies that are presently being applied to analyze clinical specimens. We also discuss the various recurrent methylation changes that have been reported for oral malignancy (including those genes frequently silenced by promoter methylation and the small RNAs with activity modulated by methylation changes) and describe surrogate disease markers identified via epigenetic analysis of saliva and blood specimens from patients with oral cancer.
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spelling pubmed-33567072012-05-29 Methylation-Mediated Molecular Dysregulation in Clinical Oral Malignancy Towle, Rebecca Garnis, Cathie J Oncol Review Article Herein we provide a concise review of the state of methylation research as it pertains to clinical oral cancerous and precancerous tissues. We provide context for ongoing research efforts in this field and describe technologies that are presently being applied to analyze clinical specimens. We also discuss the various recurrent methylation changes that have been reported for oral malignancy (including those genes frequently silenced by promoter methylation and the small RNAs with activity modulated by methylation changes) and describe surrogate disease markers identified via epigenetic analysis of saliva and blood specimens from patients with oral cancer. Hindawi Publishing Corporation 2012 2012-05-07 /pmc/articles/PMC3356707/ /pubmed/22645611 http://dx.doi.org/10.1155/2012/170172 Text en Copyright © 2012 R. Towle and C. Garnis. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Towle, Rebecca
Garnis, Cathie
Methylation-Mediated Molecular Dysregulation in Clinical Oral Malignancy
title Methylation-Mediated Molecular Dysregulation in Clinical Oral Malignancy
title_full Methylation-Mediated Molecular Dysregulation in Clinical Oral Malignancy
title_fullStr Methylation-Mediated Molecular Dysregulation in Clinical Oral Malignancy
title_full_unstemmed Methylation-Mediated Molecular Dysregulation in Clinical Oral Malignancy
title_short Methylation-Mediated Molecular Dysregulation in Clinical Oral Malignancy
title_sort methylation-mediated molecular dysregulation in clinical oral malignancy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356707/
https://www.ncbi.nlm.nih.gov/pubmed/22645611
http://dx.doi.org/10.1155/2012/170172
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AT garniscathie methylationmediatedmoleculardysregulationinclinicaloralmalignancy

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