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Epigenetic Dysregulation in Laryngeal Squamous Cell Carcinoma

Laryngeal carcinoma is a common head and neck cancer with poor prognosis. Patients with laryngeal carcinoma usually present late leading to the reduced treatment efficacy and high rate of recurrence. Despite the advance in the use of molecular markers for monitoring human cancers in the past decades...

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Autores principales: Wong, Thian-Sze, Gao, Wei, Li, Zeng-Hong, Chan, Jimmy Yu-Wai, Ho, Wai-Kuen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356733/
https://www.ncbi.nlm.nih.gov/pubmed/22645613
http://dx.doi.org/10.1155/2012/739461
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author Wong, Thian-Sze
Gao, Wei
Li, Zeng-Hong
Chan, Jimmy Yu-Wai
Ho, Wai-Kuen
author_facet Wong, Thian-Sze
Gao, Wei
Li, Zeng-Hong
Chan, Jimmy Yu-Wai
Ho, Wai-Kuen
author_sort Wong, Thian-Sze
collection PubMed
description Laryngeal carcinoma is a common head and neck cancer with poor prognosis. Patients with laryngeal carcinoma usually present late leading to the reduced treatment efficacy and high rate of recurrence. Despite the advance in the use of molecular markers for monitoring human cancers in the past decades, there are still no reliable markers for use to screen laryngeal carcinoma and follow the patients after treatment. Epigenetics emerged as an important field in understanding the biology of the human malignancies. Epigenetic alterations refer to the dysregulation of gene, which do not involve the alterations of the DNA sequence. Major epigenetic changes including methylation imbalance, histone modification, and small RNA dysregulation could play a role in the development of human malignancies. Global epigenetic change is now regarded as a molecular signature of cancer. The characteristics and behavior of a cancer could be predicted based on the specific epigenetic pattern. We here provide a review on the understanding of epigenetic dysregulation in laryngeal carcinoma. Further knowledge on the initiation and progression of laryngeal carcinoma at epigenetic level could promote the translation of the knowledge to clinical use.
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spelling pubmed-33567332012-05-29 Epigenetic Dysregulation in Laryngeal Squamous Cell Carcinoma Wong, Thian-Sze Gao, Wei Li, Zeng-Hong Chan, Jimmy Yu-Wai Ho, Wai-Kuen J Oncol Review Article Laryngeal carcinoma is a common head and neck cancer with poor prognosis. Patients with laryngeal carcinoma usually present late leading to the reduced treatment efficacy and high rate of recurrence. Despite the advance in the use of molecular markers for monitoring human cancers in the past decades, there are still no reliable markers for use to screen laryngeal carcinoma and follow the patients after treatment. Epigenetics emerged as an important field in understanding the biology of the human malignancies. Epigenetic alterations refer to the dysregulation of gene, which do not involve the alterations of the DNA sequence. Major epigenetic changes including methylation imbalance, histone modification, and small RNA dysregulation could play a role in the development of human malignancies. Global epigenetic change is now regarded as a molecular signature of cancer. The characteristics and behavior of a cancer could be predicted based on the specific epigenetic pattern. We here provide a review on the understanding of epigenetic dysregulation in laryngeal carcinoma. Further knowledge on the initiation and progression of laryngeal carcinoma at epigenetic level could promote the translation of the knowledge to clinical use. Hindawi Publishing Corporation 2012 2012-05-07 /pmc/articles/PMC3356733/ /pubmed/22645613 http://dx.doi.org/10.1155/2012/739461 Text en Copyright © 2012 Thian-Sze Wong et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wong, Thian-Sze
Gao, Wei
Li, Zeng-Hong
Chan, Jimmy Yu-Wai
Ho, Wai-Kuen
Epigenetic Dysregulation in Laryngeal Squamous Cell Carcinoma
title Epigenetic Dysregulation in Laryngeal Squamous Cell Carcinoma
title_full Epigenetic Dysregulation in Laryngeal Squamous Cell Carcinoma
title_fullStr Epigenetic Dysregulation in Laryngeal Squamous Cell Carcinoma
title_full_unstemmed Epigenetic Dysregulation in Laryngeal Squamous Cell Carcinoma
title_short Epigenetic Dysregulation in Laryngeal Squamous Cell Carcinoma
title_sort epigenetic dysregulation in laryngeal squamous cell carcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356733/
https://www.ncbi.nlm.nih.gov/pubmed/22645613
http://dx.doi.org/10.1155/2012/739461
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