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Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease
In Alzheimer disease (AD) patient brains, the accumulation of amyloid-β (Aβ) peptides is associated with activated microglia. Aβ is derived from the amyloid precursor protein; two major forms of Aβ, that is, Aβ1-40 (Aβ40) and Aβ1-42 (Aβ42), exist. We previously reported that rat microglia phagocytos...
Autores principales: | Takata, Kazuyuki, Takada, Tetsuya, Ito, Aina, Asai, Mayo, Tawa, Manami, Saito, Yuki, Ashihara, Eishi, Tomimoto, Hidekazu, Kitamura, Yoshihisa, Shimohama, Shun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357001/ https://www.ncbi.nlm.nih.gov/pubmed/22645697 http://dx.doi.org/10.1155/2012/685739 |
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