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Association between alveolar bone loss and serum C-reactive protein levels in aggressive and chronic periodontitis patients

BACKGROUND: C-reactive protein (CRP) is an acute phase reactant that is produced in response to diverse inflammatory stimuli, and is known predictor of cardiovascular disease risk. Aggressive and chronic periodontitis are two main forms of periodontal disease, which differ mainly in the method of di...

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Autores principales: Chopra, Rahul, Patil, Sudhir R., Kalburgi, Nagaraj B., Mathur, Shivani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357029/
https://www.ncbi.nlm.nih.gov/pubmed/22628959
http://dx.doi.org/10.4103/0972-124X.94600
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author Chopra, Rahul
Patil, Sudhir R.
Kalburgi, Nagaraj B.
Mathur, Shivani
author_facet Chopra, Rahul
Patil, Sudhir R.
Kalburgi, Nagaraj B.
Mathur, Shivani
author_sort Chopra, Rahul
collection PubMed
description BACKGROUND: C-reactive protein (CRP) is an acute phase reactant that is produced in response to diverse inflammatory stimuli, and is known predictor of cardiovascular disease risk. Aggressive and chronic periodontitis are two main forms of periodontal disease, which differ mainly in the method of disease progression. This study aims at determining and comparing the relative levels of serum CRP and alveolar bone loss in aggressive and chronic periodontitis patients. MATERIALS AND METHODS: A total of 45 subjects, which were divided into 3 groups diagnosed as having generalized aggressive periodontitis (GAP), chronic generalized periodontitis (CGP) and non-periodontitis controls (NP), were selected for the study. Venous blood samples were collected for quantitative CRP analysis using Turbidimetric immunoassay. Alveolar bone loss (ABL) was measured at proximal sites of posterior teeth on a panoramic radiograph. The relationship between the mean ratio of ABL to root length and serum CRP levels was statistically analyzed using Student unpaired t-test, analysis of variance (ANOVA) and Pearson's correlation coefficient. RESULTS: Mean CRP levels were significantly greater in both GAP (7.49±2.31 mg/l) and CGP (4.88±1.80 mg/l) groups as compared to NP (0.68±0.23 mg/l) with P value <0.0001. The mean value of ABL (%) was 31.58 in CGP group and 36.77 in the GAP group, the difference being statistically significant (P=0.0079). Correlation coefficient between CRP and ABL is 0.9310 in CGP, and 0.9252 in GAP, which indicates a positive correlation between both variables. CONCLUSION: Both forms of periodontitis are associated with increased systemic inflammatory response with aggressiveness of disease progression determining the degree of response.
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spelling pubmed-33570292012-05-24 Association between alveolar bone loss and serum C-reactive protein levels in aggressive and chronic periodontitis patients Chopra, Rahul Patil, Sudhir R. Kalburgi, Nagaraj B. Mathur, Shivani J Indian Soc Periodontol Original Article BACKGROUND: C-reactive protein (CRP) is an acute phase reactant that is produced in response to diverse inflammatory stimuli, and is known predictor of cardiovascular disease risk. Aggressive and chronic periodontitis are two main forms of periodontal disease, which differ mainly in the method of disease progression. This study aims at determining and comparing the relative levels of serum CRP and alveolar bone loss in aggressive and chronic periodontitis patients. MATERIALS AND METHODS: A total of 45 subjects, which were divided into 3 groups diagnosed as having generalized aggressive periodontitis (GAP), chronic generalized periodontitis (CGP) and non-periodontitis controls (NP), were selected for the study. Venous blood samples were collected for quantitative CRP analysis using Turbidimetric immunoassay. Alveolar bone loss (ABL) was measured at proximal sites of posterior teeth on a panoramic radiograph. The relationship between the mean ratio of ABL to root length and serum CRP levels was statistically analyzed using Student unpaired t-test, analysis of variance (ANOVA) and Pearson's correlation coefficient. RESULTS: Mean CRP levels were significantly greater in both GAP (7.49±2.31 mg/l) and CGP (4.88±1.80 mg/l) groups as compared to NP (0.68±0.23 mg/l) with P value <0.0001. The mean value of ABL (%) was 31.58 in CGP group and 36.77 in the GAP group, the difference being statistically significant (P=0.0079). Correlation coefficient between CRP and ABL is 0.9310 in CGP, and 0.9252 in GAP, which indicates a positive correlation between both variables. CONCLUSION: Both forms of periodontitis are associated with increased systemic inflammatory response with aggressiveness of disease progression determining the degree of response. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3357029/ /pubmed/22628959 http://dx.doi.org/10.4103/0972-124X.94600 Text en Copyright: © Journal of Indian Society of Periodontology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chopra, Rahul
Patil, Sudhir R.
Kalburgi, Nagaraj B.
Mathur, Shivani
Association between alveolar bone loss and serum C-reactive protein levels in aggressive and chronic periodontitis patients
title Association between alveolar bone loss and serum C-reactive protein levels in aggressive and chronic periodontitis patients
title_full Association between alveolar bone loss and serum C-reactive protein levels in aggressive and chronic periodontitis patients
title_fullStr Association between alveolar bone loss and serum C-reactive protein levels in aggressive and chronic periodontitis patients
title_full_unstemmed Association between alveolar bone loss and serum C-reactive protein levels in aggressive and chronic periodontitis patients
title_short Association between alveolar bone loss and serum C-reactive protein levels in aggressive and chronic periodontitis patients
title_sort association between alveolar bone loss and serum c-reactive protein levels in aggressive and chronic periodontitis patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357029/
https://www.ncbi.nlm.nih.gov/pubmed/22628959
http://dx.doi.org/10.4103/0972-124X.94600
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