Physiologically Based Pharmacokinetic Modeling of Tamoxifen and its Metabolites in Women of Different CYP2D6 Phenotypes Provides New Insight into the Tamoxifen Mass Balance

Tamoxifen is a first-line endocrine agent in the mechanism-based treatment of estrogen receptor positive (ER(+)) mammary carcinoma and applied to breast cancer patients all over the world. Endoxifen is a secondary and highly active metabolite of tamoxifen that is formed among others by the polymorph...

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Detalles Bibliográficos
Autores principales: Dickschen, Kristin, Willmann, Stefan, Thelen, Kirstin, Lippert, Jörg, Hempel, Georg, Eissing, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357105/
https://www.ncbi.nlm.nih.gov/pubmed/22661948
http://dx.doi.org/10.3389/fphar.2012.00092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357105/
https://www.ncbi.nlm.nih.gov/pubmed/22661948
http://dx.doi.org/10.3389/fphar.2012.00092

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