Parvovirus 4 Infection and Clinical Outcome in High-Risk Populations

Parvovirus 4 (PARV4) is a DNA virus frequently associated with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections, but its clinical significance is unknown. We studied the prevalence of PARV4 antibodies in 2 cohorts of HIV- and HCV-infected individuals (n = 469) and the correl...

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Autores principales: Simmons, Ruth, Sharp, Colin, McClure, C. Patrick, Rohrbach, Janine, Kovari, Helen, Frangou, Eleni, Simmonds, Peter, Irving, Will, Rauch, Andri, Bowness, Paul, Klenerman, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357136/
https://www.ncbi.nlm.nih.gov/pubmed/22492853
http://dx.doi.org/10.1093/infdis/jis291
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author Simmons, Ruth
Sharp, Colin
McClure, C. Patrick
Rohrbach, Janine
Kovari, Helen
Frangou, Eleni
Simmonds, Peter
Irving, Will
Rauch, Andri
Bowness, Paul
Klenerman, Paul
author_facet Simmons, Ruth
Sharp, Colin
McClure, C. Patrick
Rohrbach, Janine
Kovari, Helen
Frangou, Eleni
Simmonds, Peter
Irving, Will
Rauch, Andri
Bowness, Paul
Klenerman, Paul
author_sort Simmons, Ruth
collection PubMed
description Parvovirus 4 (PARV4) is a DNA virus frequently associated with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections, but its clinical significance is unknown. We studied the prevalence of PARV4 antibodies in 2 cohorts of HIV- and HCV-infected individuals (n = 469) and the correlations with disease status. We found that PARV4 infection frequently occurred in individuals exposed to bloodborne viruses (95% in HCV-HIV coinfected intravenous drug users [IDUs]). There were no correlations between PARV4 serostatus and HCV outcomes. There was, however, a significant association with early HIV-related symptoms, although because this was tightly linked to both HCV status and clinical group (IDU), the specific role of PARV4 is not yet clear.
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spelling pubmed-33571362012-05-21 Parvovirus 4 Infection and Clinical Outcome in High-Risk Populations Simmons, Ruth Sharp, Colin McClure, C. Patrick Rohrbach, Janine Kovari, Helen Frangou, Eleni Simmonds, Peter Irving, Will Rauch, Andri Bowness, Paul Klenerman, Paul J Infect Dis Major Articles and Brief Reports Parvovirus 4 (PARV4) is a DNA virus frequently associated with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections, but its clinical significance is unknown. We studied the prevalence of PARV4 antibodies in 2 cohorts of HIV- and HCV-infected individuals (n = 469) and the correlations with disease status. We found that PARV4 infection frequently occurred in individuals exposed to bloodborne viruses (95% in HCV-HIV coinfected intravenous drug users [IDUs]). There were no correlations between PARV4 serostatus and HCV outcomes. There was, however, a significant association with early HIV-related symptoms, although because this was tightly linked to both HCV status and clinical group (IDU), the specific role of PARV4 is not yet clear. Oxford University Press 2012-06-15 2012-04-05 /pmc/articles/PMC3357136/ /pubmed/22492853 http://dx.doi.org/10.1093/infdis/jis291 Text en © The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. http://creativecommons.org/licenses/by-nc/2.5/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/byc/3.0), which permits unrestricted nonommercial use, distribution, and reproduction in any medium, provided the original work is properly cited
spellingShingle Major Articles and Brief Reports
Simmons, Ruth
Sharp, Colin
McClure, C. Patrick
Rohrbach, Janine
Kovari, Helen
Frangou, Eleni
Simmonds, Peter
Irving, Will
Rauch, Andri
Bowness, Paul
Klenerman, Paul
Parvovirus 4 Infection and Clinical Outcome in High-Risk Populations
title Parvovirus 4 Infection and Clinical Outcome in High-Risk Populations
title_full Parvovirus 4 Infection and Clinical Outcome in High-Risk Populations
title_fullStr Parvovirus 4 Infection and Clinical Outcome in High-Risk Populations
title_full_unstemmed Parvovirus 4 Infection and Clinical Outcome in High-Risk Populations
title_short Parvovirus 4 Infection and Clinical Outcome in High-Risk Populations
title_sort parvovirus 4 infection and clinical outcome in high-risk populations
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357136/
https://www.ncbi.nlm.nih.gov/pubmed/22492853
http://dx.doi.org/10.1093/infdis/jis291
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