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Bile Acids Acutely Stimulate Insulin Secretion of Mouse β-Cells via Farnesoid X Receptor Activation and K(ATP) Channel Inhibition

Type 2 diabetes mellitus is associated with alterations in bile acid (BA) signaling. The aim of our study was to test whether pancreatic β-cells contribute to BA-dependent regulation of glucose homeostasis. Experiments were performed with islets from wild-type, farnesoid X receptor (FXR) knockout (K...

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Detalles Bibliográficos
Autores principales:	Düfer, Martina, Hörth, Katrin, Wagner, Rebecca, Schittenhelm, Björn, Prowald, Susanne, Wagner, Thomas F.J., Oberwinkler, Johannes, Lukowski, Robert, Gonzalez, Frank J., Krippeit-Drews, Peter, Drews, Gisela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357280/ https://www.ncbi.nlm.nih.gov/pubmed/22492528 http://dx.doi.org/10.2337/db11-0815

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